159053-44-8 Usage
General Description
2-Oxo-1,2,3,4-tetrahydroquinoline-6-carbonitrile is a chemical compound with the molecular formula C11H9N3O. It is a heterocyclic compound that contains a quinoline ring and a carbonitrile functional group. 2-Oxo-1,2,3,4-tetrahydroquinoline-6-carbonitrile is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. Its unique structure and chemical properties make it a versatile intermediate in organic synthesis. It has potential applications in medicinal chemistry and drug discovery due to its ability to modify the biological activity of target molecules. It is also used as a reagent in the synthesis of various heterocyclic compounds for pharmaceutical and agrochemical industries. Overall, 2-Oxo-1,2,3,4-tetrahydroquinoline-6-carbonitrile plays a crucial role in the organic synthesis of biologically active molecules and has a wide range of potential applications in the field of medicinal chemistry and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 159053-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,0,5 and 3 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 159053-44:
(8*1)+(7*5)+(6*9)+(5*0)+(4*5)+(3*3)+(2*4)+(1*4)=138
138 % 10 = 8
So 159053-44-8 is a valid CAS Registry Number.
159053-44-8Relevant articles and documents
Visible-Light Induced C(sp2)?H Amidation with an Aryl–Alkyl σ-Bond Relocation via Redox-Neutral Radical–Polar Crossover
Chang, Sukbok,Jeong, Jiwoo,Jung, Hoimin,Keum, Hyeyun,Kim, Dongwook
supporting information, p. 25235 - 25240 (2021/10/25)
We report an approach for the intramolecular C(sp2)?H amidation of N-acyloxyamides under photoredox conditions to produce δ-benzolactams with an aryl-alkyl σ-bond relocation. Computational studies on the designed reductive single electron transfer strategy led us to identify N-[3,5-bis(trifluoromethyl)benzoyl] group as the most effective amidyl radical precursor. Upon the formation of an azaspirocyclic radical intermediate by the selective ipso-addition with outcompeting an ortho-attack, radical–polar crossover was then rationalized to lead to the rearomative ring-expansion with preferential C?C bond migration.
