159054-14-5

Basic information

• Product Name: ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE
• Synonyms: ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE;3-[(1E)-2-Carboxyethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid ethyl ester;(E)-3-(4,6-dichloro-2-(ethoxycarbonyl)-1H-indol-3-yl)acrylic acid;3-(4,6-Dichloro-2-(ethoxycarbonyl)-1H-indol-3-yl)acrylic acid
• CAS NO: 159054-14-5
• Molecular Formula: C₁₄H₁₁Cl₂NO₄
• Molecular Weight: 328.15
• Mol File: 159054-14-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.520
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE(159054-14-5)
• EPA Substance Registry System: ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE(159054-14-5)

Safety Data

• Hazardous Substances Data: 159054-14-5(Hazardous Substances Data)

Usage

General Description

ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE is a chemical compound with a molecular formula C16H13Cl2NO4. It is a derivative of indole with two carboxyl groups and two chlorine atoms attached to the aromatic ring. ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE is commonly used in organic synthesis and pharmaceutical research as a substrate or intermediate in the production of various pharmaceutical products. It has potential applications in the development of drugs and agrochemicals due to its structural properties and reactivity. Additionally, it may also have potential uses in the field of materials science and as a building block for the synthesis of complex organic molecules.

Upstream product

• 137836-38-5 (E)-ethyl 2-(2-(3,5-dichlorophenyl)hydrazono)propanoate 
• 626-43-7 3,5-Dichloroaniline 
• 53995-82-7 4,6-dichloro-indole-2-carboxylic acid,ethyl ester 
• 153435-96-2 ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate 
• 159054-13-4 ethyl (E)-3-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)-4,6-dichloro-1H-indole-2-carboxylate 

Downstream Products

• 223457-15-6 3-<2-(cyclohexylaminocarbonyl)ethenyl>-4,6-dichloroindole-2-carboxylic acid ethyl ester 
• 182314-96-1 4,6-dichloro-3-[2-(4-{[3-(tetrahydro-pyran-4-yl)-ureido]-methyl}-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester 
• 182314-94-9 4,6-dichloro-3-(2-{4-[3-(4-methoxy-phenyl)-ureidomethyl]-phenylcarbamoyl}-vinyl)-1H-indole-2-carboxylic acid ethyl ester 
• 182315-01-1 4,6-dichloro-3-{2-[4-(3-ethoxycarbonylmethyl-ureidomethyl)-phenylcarbamoyl]-vinyl}-1H-indole-2-carboxylic acid ethyl ester 
• 182314-99-4 4,6-dichloro-3-(2-{4-[(3-pyridin-3-yl-ureido)-methyl]-phenylcarbamoyl}-vinyl)-1H-indole-2-carboxylic acid ethyl ester 
• 182314-72-3 4,6-dichloro-3-(2-{4-[(3-phenyl-ureido)-methyl]-phenylcarbamoyl}-vinyl)-1H-indole-2-carboxylic acid ethyl ester 
• 182314-86-9 4,6-dichloro-3-(2-{4-[(3-cyclopropyl-ureido)-methyl]-phenylcarbamoyl}-vinyl)-1H-indole-2-carboxylic acid ethyl ester 
• 182315-22-6 3-{2-[4-(2-tert-butoxycarbonylamino-ethyl)-phenylcarbamoyl]-vinyl}-4,6-dichloro-1H-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists

The indole derivative, 3-((E)-3-((3-((E)-2-(7-chloroquinolin-2yl)vinyl)phenyl)amino)-3-oxoprop-1-en-1-yl)-7-methoxy-1H-indole-2-carboxylic acid (17k), was identified as a novel and highly potent and selective CysLT1 antagonist with IC50 values of 0.0059 ± 0.0011 and 15 ± 4 μM for CysLT1 and CysLT2, respectively.

Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site

A series of indole-2-carboxylates bearing suitable chains at the C-3 position of the indole nucleus was synthesized and evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions ind