159058-69-2

Usage

Uses

Used in Fragrance Industry:
(5-Ethyl-thiophen-2-yl)-methanol is used as a key component in the creation of fragrances due to its strong, sweet, and fruity odor. Its unique scent profile contributes to the development of various perfumes and scented products, enhancing their appeal and complexity.
Used in Flavor Industry:
In the flavor industry, (5-Ethyl-thiophen-2-yl)-methanol is utilized as an additive to impart its characteristic sweet and fruity taste to a range of food and beverage products. (5-Ethyl-thiophen-2-yl)-methanol helps in creating more diverse and rich flavor profiles, satisfying consumer preferences for unique and enjoyable flavors.
Used in Pharmaceutical Industry:
(5-Ethyl-thiophen-2-yl)-methanol serves as an essential intermediate in the synthesis of various pharmaceutical compounds. Its role in the development of new drugs highlights its importance in the pharmaceutical sector, contributing to the advancement of medical treatments and therapies.
Used in Organic Synthesis:
As an intermediate in organic synthesis, (5-Ethyl-thiophen-2-yl)-methanol is employed in the production of other organic compounds. Its versatility in chemical reactions allows for the creation of a wide array of products, further expanding its utility and relevance in the chemical industry.
Safety Precautions:
Given its flammable nature, (5-Ethyl-thiophen-2-yl)-methanol requires careful handling and storage to prevent fire hazards. It is crucial to adhere to proper safety protocols when working with this chemical, including avoiding exposure to heat or ignition sources, to ensure safe handling and prevent accidents.

Upstream product

• 36880-33-8 5-ethyl-thiophene-2-carbaldehyde 

Downstream Products

• 192810-13-2 (5-ethyl-2-thiophene-yl)methyl benzoate 

Relevant academic research and scientific papers

Synthesis and biological evaluation of pseudolaric acid B derivatives as potential immunosuppressive agents

Pseudolaric acid B (PB) derivatives with immunosuppressive activity were found by our group. In order to find potential immunosuppressive agents with high efficacy and low toxicity, a series of novel PB derivatives were synthesized and evaluated on their immunosuppressive activities. Most of the synthesized compounds were tested in vitro on murine T and B proliferation. In particular, compound 11 exhibited excellent inhibitory activity toward murine T cells (up to 19-fold enhancement compared to that of mycophenolatemofetil) and little cytotoxicity toward normal murine spleen cells. These experimental data demonstrated that some of these PB derivatives have great potential for future immunosuppressive studies.

Oligomerization of the Thiophene-Based p-Quinodimethanes 2,5-dihydrothiophene and 2-Ethylidene-5-methylene-2,5-dihydrothiophene

Flash vacuum pyrolysis (FVP) of (5-methyl-2-thiophene-yl)methyl benzoate (8) produces in ca. 75% yield 2,5-dimethylene-2,3-dihydrothiophene, S-monomer (3). S-Monomer 3 is relatively stable dissolved in carbon disulfide-chloroform at -78°C. The structure of 3 is confirmed by its spectral properties. When a 0.17 M solution of S-monomer 3 was allowed to warm to room temperature, SS-dimer 5 ([2,2](2,5)thiophenophane, 14.7%), SSS-trimer 7 ([2,2,2](2,5)thiophenophane, 44.3%), and polymer were produced. A small amount ( 1%) of an SSSS-tetramer was detected by GC/MS. The mechanism proposed for the formation of these oligomers involves the combination of two molecules of 3 to give an intermediate diradical (11) that can close to form dimer 5 or react with additional molecules of 3 to form the higher oligomers. Evidence for the trapping of diradical 11 by 2,5-dimethylene-2,5-dihydrofuran (O-monomer 2) was obtained. Co-oligomerization of S-monomer 3 and O-monomer 2 gave four compounds containing the thiophene moiety: OS-dimer 16, SS-dimer 5, OSS-trimer 17, and SSS-trimer 7. Some OO-dimer 4 was produced but no OOO-trimer 6 was observed and only a trace of OOS-trimer 18 was detected. Additional support for the diradical mechanism was obtained from the study of the oligomerization of the methyl derivatives of 3, 2-ethylidene-5-methylene-2,5-dihydrothiophene (10, E and Z isomers), prepared by the FVP of (5-ethyl-2-thiophene-yl)methyl benzoate (9). Oligomerization of 10 gave several dimers and trimers including two acyclic dimers that are accounted for by intramolecular disproportionation.