15907-76-3

Upstream product

• 100-46-9 benzylamine 
• 321865-41-2 m-cyanophenyl cyclobutanecarboxylate 
• 321865-44-5 p-cyanophenyl cyclobutanecarboxylate 
• 321865-43-4 p-acetylphenyl cyclobutanecarboxylate 
• 321865-45-6 cyclobutanecarboxylic acid 4-nitrophenyl ester 
• 321865-42-3 m-nitrophenyl cyclobutanecarboxylate 
• 14924-53-9 ethyl cyclobutylcarboxylate 
• 5006-22-4 Cyclobutanecarbonyl chloride 
• 953077-11-7 cyclobutyl (1H-imidazol-1-yl)methanone 

Relevant academic research and scientific papers

Synthesis of amides from acid chlorides and amines in the bio-based solvent Cyrene

Cyrene as a bio-alternative dipolar aprotic solvent: a waste minimizing and molar efficient protocol for the synthesis of amides from acid chlorides and primary amines in the bio-available solvent Cyrene is disclosed. This protocol removed the use of toxic solvents, such as dimethylformamide and dichloromethane. A simple aqueous work-up procedure for the removal of the high boiling solvent Cyrene resulted in up to a 55-fold increase in molar efficiency (Mol E.%) versus standard operating procedures. In order to rapidly compare the molar efficiency of this process against other methodologies an Excel based Mol. E% calculator was developed that automates many of the calculations. An investigation into the hydration of Cyrene found that it readily hydrates to form a geminal diol in the presence of water and that this process is exothermic.

Mild decarboxylative activation of malonic acid derivatives by 1,1′-carbonyldiimidazole

Chemical equations presented. Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N′-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process.

Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral

A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method. The Royal Society of Chemistry.

Kinetics and mechanism of aminolysis of aryl cyclobutane-carboxylates in acetonitrile

The aminolysis of Z-aryl cyclobutanecarboxylates (II) with X-benzylamines is investigated in acetonitrile at 55.0 °C. The rates are uniformly greater by 2.2 times than the corresponding rates of aryl cyclopropanecarboxylates (III). All the selectivity par