15907-95-6Relevant articles and documents
Baxter et al.
, p. 4283 (1975)
Chromium-catalyzed ligand-free amidation of esters with anilines
Chen, Changpeng,Ling, Liang,Luo, Meiming,Zeng, Xiaoming
supporting information, p. 762 - 766 (2021/04/14)
Amides are important structural motifs in pharmaceutical and agrochemical chemistry because of the intriguing biological active properties. We report here the amidation of commercially available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution.
Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks
Chernykh, Anton V.,Melnykov, Kostiantyn P.,Tolmacheva, Nataliya A.,Kondratov, Ivan S.,Radchenko, Dmytro S.,Daniliuc, Constantin G.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Kuchkovska, Yuliya O.,Grygorenko, Oleksandr O.
, p. 8487 - 8496 (2019/08/30)
An efficient approach to synthesis of previously unavailable 2-substituted difluorocyclobutane building blocks was developed and applied on a multigram scale. The key step of the synthetic sequence included deoxofluorination of O-protected 2-(hydroxylmeth
