159097-19-5

Basic information

• Product Name: 2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole hydrochloride
• CAS NO: 159097-19-5
• Molecular Weight: 491.877
• Mol File: 159097-19-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole hydrochloride(159097-19-5)
• EPA Substance Registry System: 2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole hydrochloride(159097-19-5)

Safety Data

• Hazardous Substances Data: 159097-19-5(Hazardous Substances Data)

Upstream product

• 618-42-8 1-piperidin-1-yl-ethanone 
• 159096-54-5 2-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole 

Relevant articles and documents

5-(2-OXYPHENYL)-PYRROLE DERIVATIVES AS DOPAMINE D3 RECEPTOR ANTAGONISTS

Compounds of formula (I), STR1 wherein R 1 represents C 1-4 alkyl; and R 2, R 3, R 4 and R 5 each independently represent hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkoxyC. sub.1-4 alkyl, C 1-4 alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono-or di-alkylamino, trifluoromethyl, trifluoromethoxy, hydroxyl, hydroxyalkyl, C. sub.1-4 alkylthio, C 1-4 alkanoyl, C 1-4 alkoxycarbonyl, aminosulphonyl, alkylaminosulphonyl or dialkylaminosulphonyl; or R 1 and R 2 together form a linking chain-(CH 2) m Op (wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C 1-4 alkyl groups; and Y represents a group selected from (a) or (b) wherein R 6 and R. sup.7 independently represent hydrogen, C 1-6 alkyl, optionally substituted arylC 1-6 alkyl or optionally substituted heteroarylC 1-6 alkyl; R 8 represents C. sub.1-6 alkyl, C 3-6 alkenyl or C. sub.3-6 cycloalkylC 1-4 alkyl; and R 9 represents C 1-6 alkyl; C 3-6 alkenyl; C 3-6 cycloalkylC 1-4 alkyl, optionally substituted arylC 1-4 alkyl or optionally substituted heteroarylC 1-4 alkyl; or NR 8 R 9 forms a heterocyclic ring (with the proviso that NR 8 R 9 is not piperazine); R 10 represents C. sub.1-6 alkyl; C 3-6 alkenyl; C. sub.3-6 cycloalkylC 1-4 alkyl, optionally substituted arylC 1-4 alkyl, or optionally substituted heteroarylC 1-4 alkyl; and n is 1 to 3; and salts thereof, have affinity for dopamine D 3 receptors and may be useful in the treatment of e.g., psychotic disorders.