159117-06-3Relevant academic research and scientific papers
Enantioselective synthesis of diverse α-amino phosphonate diesters
Smith III, Amos B.,Yager, Kraig M.,Taylor, Carol M.
, p. 10879 - 10888 (2007/10/03)
An efficient, versatile protocol for the synthesis of highly enantioenriched α-amino phosphonate diesters has been devised. Addition of lithium diethyl phosphite to chiral chelating imines 31a-j, prepared from a variety of aldehydes and the chiral auxilia
Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten
Smith III, Amos B.,Taylor, Carol M.,Benkovic, Stephen J.,Hirschmann, Ralph
, p. 6853 - 6856 (2007/10/02)
Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration of scalemic α-amino phosphonate 4.
