15912-55-7

Usage

Uses

As there is limited information available about the specific applications of 1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Ethyl Ester, it is difficult to provide a comprehensive list of its uses. However, based on its chemical structure and the properties of similar compounds, potential applications may include:
Used in Pharmaceutical Industry:
1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Ethyl Ester could be used as an intermediate in the synthesis of various pharmaceutical compounds, given its heterocyclic ring and ester functional groups.
Used in Chemical Research:
Due to its rarity and unique structure, 1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Ethyl Ester may be utilized in chemical research to study the properties and reactions of heterocyclic compounds and ester derivatives.

InChI:InChI=1/C12H15NO2/c1-2-10-9-6-4-3-5-8(9)7-11(13-10)12(14)15/h3-6,10-11,13H,2,7H2,1H3,(H,14,15)/p-1

Upstream product

• 64-17-5 ethanol 
• 74163-81-8 L-Tic-OH 
• 67123-97-1 (R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 

Downstream Products

• 18881-17-9 (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline 
• 88106-00-7 N-<4-(4-hydroxyphenyl)butyryl>-L-3-carbethoxy-1,2,3,4-tetrahydro-2H-isoquinoline 
• 1254944-66-5 ethyl 2-(5-(methylthio)thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 1380547-82-9 3-ethyl 2-(3-(trifluoromethyl)phenyl) 3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate 
• 1262842-13-6 C₁₉H₂₁NO₄S 
• 1380547-84-1 3-ethyl 2-phenyl 3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate 
• 101195-64-6 ethyl 2-(phenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 1380547-77-2 C₁₉H₁₈ClNO₃ 
• 1380547-80-7 C₁₈H₁₈BrNO₄S 
• 1380548-02-6 C₃₁H₃₁NO₃ 
• 1380547-98-7 (3-(([1,1'-biphenyl]-4-yloxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone 
• 1380547-97-6 C₂₇H₂₂FNO₂ 
• 1380547-96-5 C₂₈H₂₆N₂O 
• 1380547-95-4 C₂₉H₂₆N₂O₃ 

Relevant academic research and scientific papers

Chiral tricarbonyl(η6-arene)chromium complexed diphosphanes. Highly enantioselective rhodium-mediated hydrogenation of ketones

Arenechromium complexed diastereomeric aminophosphine-phosphinite ligands derived from tetrahydroisoquinoline have been synthesised and examined as chiral auxiliaries in the hydrogenation of functionalised ketones. A cyclopentyl-substituted anti-stereoisomer is providing the highest enantioselectivities (up to >99% ee).

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates

A series of tetrahydroisoquinoline-based benzodiazepine dimers were synthesized and tested for in vitro cytotoxicity against a panel of cancer cell lines. Structure-activity relationship investigation of various spacers guided by molecular modeling studie

NATURAL KILLER CELLS

This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of IMK cells by increasing the expression of specific transcription factors associated with NK cell production.

MODULATORS OF REV-ERB

The subject matter herein concerns the identification and development of potent synthetic REV-ERB ligands, such as in vivo agonists and antagonists. These compounds allow for characterization of the effects of modulation of this receptor in vivo specifically on circadian behavior and metabolism, and have suitable characteristics for development of medicinal compounds useful for treatment of malconditions such as diabetes, obesity, atherosclerosis, dyslipidemia, a circadian rhythm disorder, coronary artery disease, bipolar disorder, depression, cancer, a sleep disorder, an anxiety disorder, an addiction disorder, a bone-related disorder such osteoporosis, a skeletal muscle disease, e.g., with compromised exercise capacity, or an autoimmune disorder such as psoriasis, multiple sclerosis, inflammatory bowel disease, and others.

An organogel formed from a cyclic β-aminoalcohol

A new organogelator with unique structural feature of a cyclic β-aminoalcohol is presented as the first example of gelation by aminoalcohol through hydrogen-bonding between hydroxy and amine.

ANTIPARASITIC TERPENE ALKALOIDS

The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation. More particularly, the present invention relates to derivatives of the terpene alkaloid (1S,2R,4aS,5R,8R,8aR)-2-(acetyloxy)-8a-hydroxy-3,8-dimethyl-5-(1-methylethenyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate. Pharmaceutical compositions comprising the same are also disclosed.

Evaluation of animal liver acetone powders for the resolution of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Butyl, ethyl and methyl esters of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid were hydrolyzed stereoselectively under very mild conditions to give the corresponding (S)-acid and the unreacted (R)-ester using readily available animal liver (chicken, mouse, rat and rabbit) acetone powders.

BENZAMIDINE DERIVATIVES SUBSTITUTED BY CYCLIC AMINO ACID AND CYCLIC HYDROXY ACID DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS

This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.