159138-81-5

Basic information

• Product Name: Benzamide,N-(aminoiminomethyl)-4-(1- methylethyl)-3-(methylsulfonyl)-,monomethanesulfonate
• Synonyms: (4-isopropyl-3-methanesulfonyl-benzoyl) guanidine methanesulfonate;Benzamide,N-(aminoiminomethyl)-4-(1- methylethyl)-3-(methylsulfonyl)-,monomethanesulfonate;HOE 642 cariporide mesilate;N- (Diaminomethylene)- 4- isopropyl- 3- (methylsulfonyl)- benzamide;N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide methanesulfonic acid;N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-yl-benzamide;Cariporide Mesilate;HOE 642
• CAS NO: 159138-81-5
• Molecular Formula: CH₄O₃S*C₁₂H₁₇N₃O₃S
• Molecular Weight: 0
• Mol File: 159138-81-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 227-230°
• Boiling Point: 542.8°Cat760mmHg
• Flash Point: 282.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 7.62E-12mmHg at 25°C
• CAS DataBase Reference: Benzamide,N-(aminoiminomethyl)-4-(1- methylethyl)-3-(methylsulfonyl)-,monomethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide,N-(aminoiminomethyl)-4-(1- methylethyl)-3-(methylsulfonyl)-,monomethanesulfonate(159138-81-5)
• EPA Substance Registry System: Benzamide,N-(aminoiminomethyl)-4-(1- methylethyl)-3-(methylsulfonyl)-,monomethanesulfonate(159138-81-5)

Safety Data

• Hazardous Substances Data: 159138-81-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H17N3O3S.CH4O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18;1-5(2,3)4/h4-7H,1-3H3,(H4,13,14,15,16);1H3,(H,2,3,4)

Upstream product

• 75-75-2 methanesulfonic acid 
• 159138-80-4 cariporide 
• 176107-23-6 4-Isopropyl-3-methanesulfonyl-benzoic acid methyl ester 
• 154117-61-0 methyl 3-methylsulfonyl-4-bromobenzoate 

Relevant articles and documents

Synthesis of the highly selective Na+/H+ exchange inhibitors cariporide mesilate and (3-methanesulfonyl-4-piperidino-benzoyl) guanidine methanesulfonate

The syntheses of cariporide mesilate ((4-isopropyl-3-methanesulfonyl-benzoyl) guanidine methanesulfonate, HOE 642, CAS 159138-81-5), currently being clinically investigated as a protective drug in cardiac ischemia and reperfusion states, and of HOE 694 ((3-methanesulfonyl-4-piperidino-benzoyl)guanidine methanesulfonate, CAS 149725-40-6), widely used as a physiological and pharmacological research tool in studies comprising Na+/H+ exchange (NHE) inhibition, are described. Additionally, their selectivity on the different subtypes is disclosed.