159152-82-6Relevant academic research and scientific papers
Reaction of 2-(polyfluoroacyl)cycloalkanones with hydroxylamine
Sevenard, Dmitri V.,Khomutov, Oleg G.,Pashkevich, Kazimir I.,Lork, Enno,Roeschenthaler, Gerd-Volker
, p. 1960 - 1972 (2007/10/03)
The 2-acylcycloalkanones 1a-g and 3a-c, possessing a polyfluoroalkyl group, react with hydroxylamine regio- and stereoselectively to yield 4,5-dihydroisoxazol-5-ols 2a-g and 4a-c, respectively, i.e., products of N-addition to the oxo group at the cycloalk
Haloacetylated Enol Ethers: 3. Synthesis of 3,3a,4,5,6,7-Hexahydro-3-halomethylbenzoisoxazoles
Martins, Marcos A. P.,Flores, Alex F. C.,Freitag, Rogerio,Zanatta, Nilo
, p. 731 - 734 (2007/10/02)
The investigation of the halomethyl group effect on the regiochemistry of the reaction of 2-acetylcyclohexanones 1a-d and β-methoxyvinyl trifluoro methyl ketone derivative 2a with hydroxylamine to afford 3,3a,4,5,6,7-hexahydro-3-halomethyl-3-hydroxybenzoisoxaloes 3a-c, and the respective dehydrated compounds 4a-c, is reported.Compounds 1a-c, 2a proved to be versatile building blocks for the regiospecific synthesis of isoxazole derivatives having a 3-halomethyl substituent, in good yields.
