159152-83-7Relevant academic research and scientific papers
The reaction of hydroxylamine with aryl trifluoromethyl-β-diketones: Synthesis of 5-hydroxy-5-trifluoromethyl-Δ2-isoxazolines and their dehydration to 5-trifluoromethylisoxazoles
Kumar, Vinod,Aggarwal, Ranjana,Singh, Shiv P.
, p. 880 - 888 (2006)
Reaction of hydroxylamine hydrochloride with aryl trifluoromethyl-β-diketones affords 5-hydroxy-5-trifluoromethyl-Δ2-isoxazolines rather than the reported 3-trifluoromethylisoxazoles. The structural assignment is based on the analysis of their
Synthesis of 3-phenyl-5-(trifluoromethyl)isoxazole and 5-phenyl-3- (trifluoromethyl)isoxazole
Pavlik, James W.,Lowell, Jennifer A.,Ervithayasuporn, Vuthichai
, p. 1253 - 1255 (2005)
Reaction of 4,4,4-trifluoro-1-phenyl-1,3-butanedione with hydroxylamine led to the formation of 5-hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole which was dehydrated to 3-phenyl-5-(trifluoromethyl)isoxazole. This isomer can also be synthesized
ISOXAZOLE-IMIDAZOLE DERIVATIVES
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Page/Page column 12, (2009/01/24)
The present invention is concerned isoxazole-imidazole derivatives having affinity and selectivity for GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use for enhancing cognition or for the treatment of cognitive disorders like Alzheimer's disease. In particular, the present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula I wherein R1, R2 and R3 are as described in the specification.
ISOXAZOLE-PYRIDINE DERIVATIVES
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Page/Page column 37, (2009/06/27)
The present invention is concerned with isoxazole-pyridine derivatives of formula I wherein X, R1 to R6 are as described herein. The compounds are active on the GABA A α5 receptor binding site and useful for the treatment of cognitive disorders, such as Alzheimer's disease.
Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles
Martins, Marcos A. P.,Machado, Pablo,Piovesan, Luciana A.,Flores, Alex F. C.,De Campos, Marli M. A.,Scheidt, Carolina,Bonacorso, Helio G.,Zanatta, Nilo
experimental part, p. 985 - 990 (2009/10/10)
A series of twelve 5-trihalomethyl-3-arylisoxazoles was synthesized and screened for antibacterial and antifungal activities. The compounds were synthesized from the cyclondensation of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones [CX 3C(O)C(R 2/
Haloacetylated Enol Ethers. 7 [7]. Synthesis of 3-Aryl-5-trihalomethylisoxazoles and 3-Aryl-5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles
Martins, Marcos A. P.,Siqueira, Geonir M.,Bastos, Giovani P.,Bonacorso, Helio G.,Zanatta, Nilo
, p. 1619 - 1622 (2007/10/03)
β-Aryl-β-methoxyvinyl trihalomethyl ketones 1a-g, 2a-g [aryl = p-YC6H4 where Y= H, Me, OMe, F, Cl, Br, NO2] are cyclocondensed with hydroxylamine hydrochloride to afford the 3-aryl-5-hydroxy-5-trihalomethyl-4,5-dihydroisox
