15917-65-4

Usage

Uses

Used in Pharmaceutical Industry:
N-Desmethyl Tamoxifen Hydrochloride is used as an active pharmaceutical ingredient for the treatment of breast cancer. As a metabolite of Tamoxifen, it contributes to the drug's overall effectiveness in combating the disease by modulating estrogen receptor activity and inhibiting tumor growth.
Used in Research and Development:
N-Desmethyl Tamoxifen Hydrochloride is used as an internal standard in high-performance liquid chromatography (HPLC) for the quantification of metabolites from NG2 cell-derived astrocytes. This application aids in the accurate measurement and analysis of various biomarkers, facilitating research in the field of neuroscience and cancer biology.
Used in Quality Control and Standardization:
Due to its stable and well-defined chemical properties, N-Desmethyl Tamoxifen Hydrochloride is utilized as a reference compound in the quality control and standardization of Tamoxifen-based pharmaceutical products. This ensures the consistency, efficacy, and safety of these medications for patients.

Biochem/physiol Actions

N-Desmethyltamoxifen HCl is the primary metabolite of tamoxifen. N-Desmethyltamoxifen HCl is an estrogen response modifer and protein kinase C inhibitor.

InChI:InChI=1/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;

Upstream product

• 10540-29-1 tamoxifen 

Relevant academic research and scientific papers

A new selective fluorescent probe based on tamoxifen

Developing targeted validation probes that can interrogate biology is of interest for both chemists and biologists. The synthesis of suitable compounds provides a means for avoiding the costly labeling of cells with specific antibodies and the bias associ

Functional inhibition of intestinal and uterine muscles by non-permeant triphenylethylene derivatives

We have previously shown that the triphenylethylene antiestrogen tamoxifen reversibly inhibited spontaneous contractile activity in isolated duodenal muscle. Now, we have synthesized different quaternary ammonium salts of tamoxifen by changing the substit

Photochemical internalization of tamoxifens transported by a "trojan-horse" nanoconjugate into breast-cancer cell lines

Photochemical internalization (PCI) has shown great promise as a therapeutic alternative for targeted drug delivery by light-harnessed activation. However, it has only been applicable to therapeutic macromolecules or medium-sized molecules. Herein we desc

Temperature-responsive self-assemblies of 'kinked' amphiphiles

The synthesis of novel norbornane-based amphiphiles and the thermal response of their corresponding colloids is presented. It was found that the hydrodynamic diameter (DH) expansion or contraction of 1-4 in response to increasing temperature was governed