159173-98-5Relevant academic research and scientific papers
Diastereoselective Ireland-Claisen rearrangements of substituted allyl β-amino esters: Applications in the asymmetric synthesis of C(5)-substituted transpentacins
Davies, Stephen G.,Fletcher, Ai M.,Lee, James A.,Roberts, Paul M.,Souleymanou, Myriam Y.,Thomson, James E.,Zammit, Charlotte M.
, p. 2702 - 2728 (2014/05/06)
The diastereoselective Ireland-Claisen rearrangement of a range of substituted allyl β-amino esters gave the corresponding enantiopure α-substituted-β-amino esters with good diastereoselectivity. The application of this methodology in the asymmetric synthesis of a range of C(5)-substituted 1,2-anti-1,5-syn-transpentacins was demonstrated by the rearrangement of a range of β-amino esters derived from sorbic acid, followed by esterification, ring-closing metathesis, hydrogenolytic deprotection/reduction, and hydrolysis, which gave the C(5)-substituted transpentacins in only 9 steps from commercially available starting materials. This journal is the Partner Organisations 2014.
Production method of beta-amino acid
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Page 7-8, (2010/02/08)
A production method of an optically active β-amino acid represented by the formula (I) wherein each symbol is as defined in the specification, which includes reacting a compound represented by the formula (II) with a lithium amide represented by the formu
Chemoselective debenzylation of N-benzyl tertiary amines with ceric ammonium nitrate
Bull, Steven D.,Davies, Stephen G.,Fenton, Carry,Mulvaney, Andrew W.,Shyam Prasad,Smith, Andrew D.
, p. 3765 - 3774 (2007/10/03)
Treatment of a range of N-benzyl tertiary amines with aqueous eerie ammonium nitrate results in N-debenzylation to afford the corresponding secondary amine. Chemoselective mono-W-debenzylation of N-benzyl tertiary amines is shown to occur in the presence of N-benzyl amides, O-benzyl ethers, O-benzyl esters, O-benzyl phenolates and 5-benzyl ethers. The Royal Society of Chemistry 2000.
Asymmetric Synthesis of anti-α-Alkyl-β-amino Acids
Davies, Stephen G.,Walters, Iain A. S.
, p. 1129 - 1140 (2007/10/02)
An investigation into the asymmetric induction accompanying alkylations of enolates derived from the highly diastereoselective conjugate addition of lithium (R)-N-benzyl-N-α-methylbenzylamide (R)-1 to crotonate and cinnamate esters has been performed.The
