159182-10-2Relevant articles and documents
triAZOLOtriAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS
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Page/Page column 90, (2020/01/24)
The present invention provides triazolotriazine derivatives of formula (1) as A2A receptor antagonists. Compounds of formula (1) and pharmaceutical compositions including the compounds can be used for the treatment of disorders related to A2A receptor hyperfunctioning, such as certain types cancers. Compounds of formula (1) and methods of preparing the compounds are disclosed in the invention.
INHIBITION OF BACTERIAL BIOFILMS WITH ARYL CARBAMATES
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Page/Page column 33-34; 35, (2012/02/01)
Disclosure is provided for carbamate compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.
Synthesis and application of a triazene?ferrocene modifier for immobilization and characterization of oligonucleotides at electrodes
Hansen, Majken N.,Farjami, Elaheh,Kristiansen, Martin,Clima, Lilia,Pedersen, Steen Uttrup,Daasbjerg, Kim,Ferapontova, Elena E.,Gothelf, Kurt V.
experimental part, p. 2474 - 2481 (2010/07/15)
A new DNA modifier containing triazene, ferrocene, and activated ester functionalities was synthesized and applied for electrochemical grafting and characterization of DNA at glassy carbon (GC) and gold electrodes. The modifier was synthesized from ferrocenecarboxylic acid by attaching a phenyltriazene derivative to one of the ferrocene Cp rings, while the other Cp ring containing the carboxylic acid was converted to an activated ester. The modifier was conjugated to an amine-modified DNA sequence. For immobilization of the conjugate at Au or GC electrodes, the triazene was activated by dimethyl sulfate for release of the diazonium salt. The salt was reductively converted to the aryl radical which was readily immobilized at the surface. DNA grafted onto electrodes exhibited remarkable hybridization properties, as detected through a reversible shift in the redox potential of the Fc redox label upon repeated hybridization/denaturation procedures with a complementary target DNA sequence. By using a methylene blue (MB) labeled target DNA sequence the hybridization could also be followed through the MB redox potential. Electrochemical studies demonstrated that grafting through the triazene modifier can successfully compete with existing protocols for DNA immobilization through the commonly used alkanethiol linkers and diazonium salts. Furthermore, the triazene modifier provides a practical one-step immobilization procedure.
