159182-38-4

Basic information

• Product Name: (S)-1-[2-(4-Amino-phenyl)-ethylamino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenoxy]-propan-2-ol
• CAS NO: 159182-38-4
• Molecular Weight: 416.636
• Mol File: 159182-38-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-[2-(4-Amino-phenyl)-ethylamino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenoxy]-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-[2-(4-Amino-phenyl)-ethylamino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenoxy]-propan-2-ol(159182-38-4)
• EPA Substance Registry System: (S)-1-[2-(4-Amino-phenyl)-ethylamino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenoxy]-propan-2-ol(159182-38-4)

Safety Data

• Hazardous Substances Data: 159182-38-4(Hazardous Substances Data)

Upstream product

• 13472-00-9 p-Aminophenethylamine 
• 159182-09-9 3-(4-tert-butyldimethylsilyloxyphenoxy)-2-(S)-propyleneoxide 
• 108534-47-0 4-(tert-butyldimethylsilyloxy)phenol 

Downstream Products

• 159182-39-5 [2-(4-Amino-phenyl)-ethyl]-{(S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenoxy]-2-hydroxy-propyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Potent, selective benzenesulfonamide agonists of the human β3 adrenergic receptor

A cloned human β3 adrenergic receptor assay was used to identify phenoxypropanolamine agonist 1. SAR, studies led to the identification of benzenesulfonamide derivative 20, a 6.3 nM β3 agonist which shows 30-fold selectivity for β3 agonist activity over β1 and β2 receptor binding. Further refinement of this lead provided 4-bromo derivative 39, a subnanomolar agonist with 660-fold and 230-fold selectivity over β1 and β2, respectively.