159191-01-2Relevant academic research and scientific papers
Ketone homologation to produce α-methoxyketones: Application to conduritol synthesis
Phillipson, Neil,Anson, Michael S.,Montana, John G.,Taylor, Richard J. K.
, p. 2821 - 2829 (2007/10/03)
The scope of Trost's sulfone homologation procedure for the conversion of ketones into their α-methoxylated higher homologues has been dramatically expanded. The use of zirconium (or hafnium) tetrachloride in the hydroxy sulfone rearrangement step gives g
α-Methoxyketone Synthesis via Ketone Homologation: ZrCl4-Mediated Hydroxy Sulfone Rearrangements
Montana, John G.,Phillipson, Neil,Taylor, Richard J. K.
, p. 2289 - 2290 (2007/10/02)
The adducts between ketones and the anion derived from benzene undergo efficient, regioselective rearrangement to give α-methoxyketones when treated with ZrCl4 and HfCl4; this new procedure allows the sulfone-mediated homologation
