159213-46-4

Upstream product

• 22666-84-8 4-hydroxybenzaldehyde sodium salt 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 208838-92-0 C₂₄H₂₄Cl₆N₆O₇P₄ 
• 208839-00-3 C₄₂H₅₄Cl₃N₉O₇P₄ 

Relevant academic research and scientific papers

Cavity partition and functionalization of a [2+3] organic molecular cage by inserting polar PO bonds

The cavity of a [2+3] organic molecular cage was partitioned and functionalized by inserting inner-directed PO bonds, which shows CO2 capture and CH4 exclusion due to the size-matching and polarity effects. Computational results demonstrate that the successful segmentation via polar PO bonds facilitates the CO2 molecules to reside selectively inside the cavity.

Synthesis of Tri(4-formylphenyl) Phosphonate Derivatives as Recyclable Triple-Equivalent Supports of Peptide Synthesis

To seek the novel application of organophosphorus compounds, the designed tri(4-formylphenyl) phosphonate (TFP) derivatives were successfully synthesized herein, which were used as C-terminal protecting groups of amino acid or greener triple-equivalent supports in liquid-phase peptide synthesis (LPPS). Through the support-aided precipitation effect of TFP derivatives, the peptide intermediates during peptide synthesis were separated and collected via rapid precipitation and facile filtration without chromatographic purification. Furthermore, the TFP derivative support can be directly recycled for reuse without further regeneration after being sheared from the target peptide.

Synthesis and reactivity of dendrimers based on phosphoryl (P=O) groups

The synthesis of phosphoryl-based dendrimers is described, using the reiteration of a two-steps process which gives alternatively aldehyde and P(O)Cl2 end groups. The synthesis has been carried out up to the third generation, to give a compound which bears 24 chlorine atoms on the surface. Preliminary experiments on the first generation of the dendrimer possessing either 6 CHO or 6 Cl groups show that these compounds display a versatile reactivity. For instance, α, β-unsaturated esters, crown ethers, chiral phosphine sulfides or diallylamine are grafted on the surface, and the resulting dendrimers are isolated in good to nearly quantitative yields.

Phosphorus dendrimers: A new class of macromolecules

Two ways of synthesis of phosphorus dendrimers are elaborated up to the twelfth generation for one of them, to give a molecule which possesses 12288 functions. Examples of the reactivity of some dendrimers are described.