159217-95-5

Basic information

• Product Name: Benzenamine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-
• CAS NO: 159217-95-5
• Molecular Formula: C13H23NOSi
• Molecular Weight: 237.417
• Mol File: 159217-95-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenamine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-(159217-95-5)
• EPA Substance Registry System: Benzenamine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-(159217-95-5)

Safety Data

• Hazardous Substances Data: 159217-95-5(Hazardous Substances Data)

Upstream product

• 1877-77-6 3-aminobenzenemethanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 99-61-6 3-nitro-benzaldehyde 
• 619-25-0 3-Nitrobenzyl alcohol 
• 256334-95-9 tert-butyl-dimethyl-(3-nitro-benzyloxy)-silane 

Downstream Products

• 913532-36-2 4-(3-hydroxymethyl-phenylamino)-3-nitro-benzoic acid ethyl ester 
• 913532-35-1 3-amino-4-(3-hydroxymethyl-phenylamino)-benzoic acid ethyl ester 
• 913532-34-0 1-(3-hydroxymethyl-phenyl)-1H-benzoimidazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS

The disclosure provides compounds of formula (I), or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.

NEW MALONITRILE DERIVATIVES

The invention relates to a compound of formula (I) wherein R1-R4 and A1-A2 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl)alkylphosphonate esters

Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl)phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle.