15922-44-8Relevant academic research and scientific papers
Conformational Analysis and Structural Elucidation of Spirocyclic Oxaziridines Using NMR, Crystallography, and Molecular Modeling
Usuki, Yoshinosuke,Wang, Yuguang,Aube, Jeffrey
, p. 8028 - 8035 (1995)
The 1H NMR spectra of spirocyclic oxaziridines derived from substituted cyclohexanones and benzylamines were studied.Depending on substitution and on stereochemistry, these compounds often exhibit a substantial upfield shift of the cyclohexyl methylene or methine protons with a 1,3-diaxial relationship to the oxaziridine N-substituent.This effect is ascribed to a conformation that places an aromatic group over the plane of the cyclohexane ring.This conformation has also been found in the solid state by X-ray crystallography and is supported by molecular mechanics calculations.The use of the effect in assigning stereochemistry to this series of compounds is discussed.
Sodium borohydride on wet clay: Solvent-free reductive amination of carbonyl compounds using microwaves
Varma, Rajender S.,Dahiya, Rajender
, p. 6293 - 6298 (2007/10/03)
A solvent-flee reductive amination of carbonyl compounds by wet montmorillonite K 10 clay supported sodium borohydride is described; microwave irradiation facilitates the procedure.
Method for preparing aromatic secondary amino compound
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, (2008/06/13)
Disclosed are (1) a method for preparing an aromatic secondary amino compound which comprises reacting an N-cyclohexylideneamino compound in the presence of a hydrogen moving catalyst and a hydrogen acceptor by the use of a sulfur-free polar solvent and/or a cocatalyst, and (2) a method for preparing an aromatic secondary amino compound which comprises reacting cyclohexanone or a nucleus-substituted cyclohexanone, an amine and a nitro compound corresponding to the amine in a sulfur-free polar solvent in the presence of a hydrogen moving catalyst, a cocatalyst being added or not added. In a further aspect, a method is provided for the preparation of aminodiphenylamine by reacting phenylenediamine and cyclohexanone in the presence of a hydrogen transfer catalyst in a sulfur-free polar solvent while using nitroaniline as a hydrogen acceptor.
Compound and use of the same as medicine
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, (2008/06/13)
Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate, or a pharmaceutically acceptable salt thereof. These compounds are useful as IV-type allergic reaction-suppressive drugs.
