1592250-80-0Relevant academic research and scientific papers
Regioselective Passerini and Passerini-Knoevenagel Reactions with vic-Diketo Amides
Rossbach, Jan,Harms, Klaus,Koert, Ulrich
, p. 993 - 1006 (2015/10/05)
The Passerini reaction of vic-diketo amides with a variety of isocyanides and carboxylic acids has been examined. α-Acyloxy β-keto carboxamides were formed regioselectively as the major products. For the Passerini reactions with electron-withdrawing-group-substituted acetic acids, a one-pot Passerini-Knoevenagel reaction was accomplished by the addition of triethylamine. vic-Diketo amides react with a variety of isocyanides and carboxylic acids in a regioselective Passerini three-component reaction (P-3CR) to give good to excellent yields of α-acyloxy-β-keto-carboxamides. In the case of Passerini reactions with electron-withdrawing-group-substituted acetic acids, a one-pot Passerini-Knoevenagel reaction was accomplished by the addition of triethylamine.
Regioselective passerini and passerini-knoevenagel reactions with vic-diketo amides
Rossbach, Jan,Harms, Klaus,Koert, Ulrich
, p. 993 - 1006 (2014/03/21)
The Passerini reaction of vic-diketo amides with a variety of isocyanides and carboxylic acids has been examined. α-Acyloxy β-keto carboxamides were formed regioselectively as the major products. For the Passerini reactions with electron-withdrawing-group-substituted acetic acids, a one-pot Passerini-Knoevenagel reaction was accomplished by the addition of triethylamine. vic-Diketo amides react with a variety of isocyanides and carboxylic acids in a regioselective Passerini three-component reaction (P-3CR) to give good to excellent yields of α-acyloxy-β-keto-carboxamides. In the case of Passerini reactions with electron-withdrawing-group-substituted acetic acids, a one-pot Passerini-Knoevenagel reaction was accomplished by the addition of triethylamine. Copyright
