15923-47-4Relevant articles and documents
Direct Sulfenylation of the Purine C8-H Bond with Thiophenols
Jiang, Wei,Zhuge, Juanping,Li, Jianxiao,Histand, Gary,Lin, Dongen
, p. 2415 - 2425 (2020/02/04)
The one-step copper-mediated regioselective formation of the C8-S bond for purine derivatives with arylthiols was achieved using air as the green oxidant in the presence of 1.0 equiv of Na2CO3 and stoichiometric CuCl and 1,10-phenanthroline monohydrate. This method provides an economical, easy-to-handle, and effective method for the synthesis of 8-sulfenylpurine derivatives in moderate to excellent yields. The reaction is selective for C8 over C2 and C6. It also tolerates a free amine on the purine, and it has a wide substrate scope.