1592445-57-2Relevant academic research and scientific papers
Ester derivatives of salinomycin efficiently eliminate breast cancer cells via ER-stress-induced apoptosis
Kuran, Dominika,Flis, Sylwia,Antoszczak, Micha?,Piskorek, Marlena,Huczyński, Adam
, (2021)
The polyether ionophore salinomycin (SAL) has been found to selectively target breast cancer cells, including those with stem-like phenotype. On the other hand, SAL amides and esters obtained through derivatisation of the C1 carboxyl of the ionophore were
Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin
Antoszczak, Micha?,Maj, Ewa,Stefańska, Joanna,Wietrzyk, Joanna,Janczak, Jan,Brzezinski, Bogumil,Huczyński, Adam
, p. 1724 - 1729 (2014/04/17)
A series of 11 novel amides of salinomycin were synthesized for the first time. All the obtained compounds were found to show potent antiproliferative activity against human cancer cell lines including the drug-resistant cancer cells. Four new salinomycin derivatives revealed good antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE).
