159262-88-1Relevant academic research and scientific papers
Synthesis and properties of 7-acetyl-8-aryl-9-cyano-3-hydroxy-6-methyl-3,4- dihydro-2H,8H-pyrido[2,1-6][1,3]thiazines
Krauze,Sile,Danne,Duburs
, p. 1189 - 1193 (2007/10/03)
7-Acetyl-8-aryl-2-(1-chloro-2-hydroxy-3-propyl)thio-9-cyano-6-methyl-1, 4-dihydropyndines were obtained by treatment of 1,4-dihydropyridine-2(3H)- thiones with epichlorohydrin in the presence of sodium bicarbonate. When treated with NaOMe, these compounds are readily intramolecularly alkylated with formation of 7-acetyl-8-aryl-3-hydroxy-9-cyano-6-methyl-3,4-dihydro-2H,8H- pyrido[2,1-b]-[1,3]thiazines. We have studied amination of 2-(1-chloro-2- hydroxy-3-propyl)thio-1,4-dihydropyridines and acylation of 3-hydroxy-3,4- dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines. 2005 Springer Science+Business Media, Inc.
