159266-06-5

Usage

Chemical structure

1,3-Propanediol with a 4-methylphenyl group attached to the first carbon

Usage

Precursor in the production of pharmaceuticals and perfumes

Application

Chiral resolving agent for separating enantiomers and isomers of various compounds

Physical state

Colorless, viscous liquid

Odor

Slightly sweet

Toxicity

Moderately toxic

Hazards

Prolonged or high exposure can cause irritation to eyes, skin, and respiratory system

Safety precautions

Handle with caution in a well-ventilated area

Upstream product

• 22027-51-6 3-oxo-3-p-tolyl-propionic acid methyl ester 
• 27835-00-3 ethyl (4-methylbenzoyl)acetate 
• 6921-43-3 1-cyclopropyl-4-methyl-benzene 

Downstream Products

• 1160639-62-2 C₁₇H₂₀O₄S 
• 219745-28-5 4-{2-[4-(3-Bromo-1-p-tolyl-propoxy)-phenylcarbamoyl]-phenoxy}-butyric acid ethyl ester 
• 219745-20-7 3-chloro-3-p-tolylpropan-1-ol 

Relevant academic research and scientific papers

Lewis Base-Promoted Ring-Opening 1,3-Dioxygenation of Unactivated Cyclopropanes Using a Hypervalent Iodine Reagent

A facile and effective system has been developed for the regio- and chemoselective ring-opening/electrophilic functionalization of cyclopropanes through C?C bond activation by [bis(trifluoroacetoxy)iodo]benzene with the aid of the Lewis basic promoter p-toluenesulfonamide. The p-toluenesulfonamide-promoted system works well for a wide range of cyclopropanes, resulting in the formation of 1,3-diol products in good yields and regioselectivity.

Reduction of aromatic and aliphatic keto esters using sodium borohydride/MeOH at room temperature: a thorough investigation

Reduction of keto esters is a valuable alternative to produce diols. Sodium borohydride/MeOH system at room temperature and short reaction time efficiently reduced α, β, γ, and δ-keto esters having α-keto esters as the most reactive. The ester functionality was reduced effectively due to the presence of oxo group that somehow facilitates the formation of ring intermediate. As expected, the chemoselective experiments showed that ester functionality was not reduced using this system. This study presents a simple, easy, and benign reduction process of various keto esters to its corresponding diols.

Synthesis of benzanilide derivatives as dual acting agents with α1- adrenoceptor antagonistic action and steroid 5-α reductase inhibitory activity

Synthesis of benzanilide derivatives which have dual α1-adrenoceptor antagonistic action and steroid 5α-reductase inhibitory activity and their structure-activity relationships is described.