1592683-83-4Relevant academic research and scientific papers
Synthesis of new α-Aryl-α-tetralones and α-Fluoro-α-aryl-α-tetralones, preliminary antiproliferative evaluation on drug resistant cell lines and in silico prediction of ADMETox properties
de Souza, Luana G.,Salustiano, Eduardo J.,da Costa, Kelli M.,Costa, Angela T.,Rumjanek, Vivian M.,Domingos, Jorge L.O.,Rennó, Magdalena N.,Costa, Paulo R.R.
, (2021)
α-aryl-α-tetralones and α-fluoro-α-aryl-α-tetralones derivatives were synthesized by palladium catalyzed α-arylation reaction of α-tetralones and α-fluoro-α-tetralones, with bromoarenes in moderate to good yields. These compounds were evaluated for their
Enantioselective electrophilic fluorination of α-aryl-tetralones using a preparation of N-fluoroammonium salts of cinchonine
Souza, Luana G.,de O. Domingos, Jorge L.,de A. Fernandes, Talita,Renno, Magdalena N.,Sansano, Jose M.,Najera, Carmen,Costa, Paulo R.R.
, p. 72 - 79 (2018/11/30)
The enantioselective electrophilic fluorination of α-aryl-tetralones is promoted by cinchonine/selectfluor combinations. This strategy allows a facile synthesis of the corresponding 2-fluoro-2-aryl-1-tetralones with excellent yields (up to >98%) and moder
5-Carba-pterocarpens: A new scaffold with anti-HCV activity
Fernandes, Talita de A.,Costa, Paulo R. R.,Manvar, Dinesh,Basu, Amartya,Kaushik-Basu, Neerja,Domingos, Jorge L. O.,Nichols, Daniel Brian
, p. 33 - 38 (2018/05/15)
The synthesis of a series of 5-carba-pterocarpens derivatives involving the cyclization of α-aryl-α-tetralones is described. Several compounds demonstrated potent activity and selectivity in vitro against HCV replicon reporter cells. The best profile in H
Synthesis and biological evaluation of α-aryl-α-tetralone derivatives as hepatitis C virus inhibitors
Manvar, Dinesh,Fernandes, Talita De A.,Domingos, Jorge L.O.,Baljinnyam, Erdenechimeg,Basu, Amartya,Junior, Eurides F.T.,Costa, Paulo R.R.,Kaushik-Basu, Neerja
supporting information, p. 51 - 54 (2015/02/19)
The synthesis of a novel series of 1-carba-isoflavanones through the α-arylation of α-tetralones is described. Several of these compounds demonstrated potent activity and selectivity in-vitro against HCV replicon reporter cells. Compound 10 (LQB-314) exhibited the best profile being active and selective in both replicon reporter cells (IC50 1.8 μM, SI > 111 and IC50 4.3 μM, SI > 46 in Huh7/Rep-Feo1b and Huh7.5-FGR-JC1-Rluc2A, respectively). Compound 3 (LQB-307) was the more potent and selective for Huh7.5-FGR-JC1-Rluc2A replicon reporter cells (IC50 1.5 μM, SI > 101.4).
Synthesis of 5-carbapterocarpens by α-arylation of tetralones followed by one-pot demethylation/cyclization with BBr3
Fernandes, Talita De A.,Domingos, Jorge L. O.,Da Rocha, Luiza I. A.,De Medeiros, Sabrina,Najera, Carmen,Costa, Paulo R. R.
, p. 1314 - 1320 (2014/03/21)
5-Carbapterocarpens, one of them displaying estrogenic activity, were prepared from α-aryltetralones in high yields through a one-pot, BBr 3-promoted O-demethylation and cyclization sequence. The key α-aryltetralone intermediates were obtained
Synthesis of 5-Carbapterocarpens by α-Arylation of Tetralones Followed by One-Pot Demethylation/Cyclization with BBr3
Fernandes, Talita De A.,Domingos, Jorge L. O.,Da Rocha, Luiza I. A.,De Medeiros, Sabrina,Njera, Carmen,Costa, Paulo R. R.
, p. 1314 - 1320 (2015/10/05)
5-Carbapterocarpens, one of them displaying estrogenic activity, were prepared from α-aryltetralones in high yields through a one-pot, BBr3-promoted O-demethylation and cyclization sequence. The key α-aryltetralone intermediates were obtained b
