1592875-21-2Relevant academic research and scientific papers
Synthesis and cellular uptake of p-[123I]-phenyl-amino-thiazole (123I-PAT) as a potential agent for targeting tubulin polymerization in tumors
Wang, Da-Ming,Kuo, Jia-Wei,Kuo, Wei-Ti,Hsu, Cheng-Fang,Wang, Mei-Hui,Chang, Yu,Lin, Wuu-Jyh,Wang, Jen-Tsung
, p. 132 - 135 (2014/04/03)
The phenyl-amino-thiazole (PAT) templates of methoxylbenzoyl-aryl-thiazole are potent agents against cancer by inhibiting tubulin polymerization in the nanomolar range. Herein, a radioiodinated PAT, [123I]-PAT 1, was prepared via a tributylstannyl precursor and [123I]iodide through electrophilic aromatic radioiodination. Radiolabelling of [123I]-PAT 1 was achieved in less than 15 min, with a radiochemical purity of over 99%. The accumulated radioactivity in tumor cellular uptake experiments suggested that [123I]-PAT could serve as a potential radioprobe for targeting tumor cells. Copyright
