159291-08-4Relevant academic research and scientific papers
Design and photophysical properties of new RGD targeted tetraphenylchlorins and porphyrins
Boisbrun, Michel,Vanderesse, Régis,Engrand, Philippe,Olié, Alexis,Hupont, Sébastien,Regnouf-de-Vains, Jean-Bernard,Frochot, Céline
, p. 3494 - 3504 (2008)
The synthesis, characterization, fluorescence, and singlet oxygen quantum yields of tetraphenylporphyrin and tetraphenylchlorin coupled to RGD type peptide are reported. C-terminus protected RGD derivatives were synthesized in liquid phase at the gram scale via an efficient convergent process. C-terminus unprotected RGD derivatives were synthesized on solid support. The UV-vis, fluorescence, and singlet emission spectra showed that the photophysical properties of the photosensitizers were retained in all compounds and some of them are very promising for potential PDT applications.
