1592942-85-2

Upstream product

• 220630-32-0 (2-azido-5-chlorophenyl)methanol 
• 916664-23-8 2-azido 5-chlorobenzaldehyde 
• 1630040-94-6 C₁₆H₁₉ClN₄O₃ 
• 1592942-61-4 2-(2-azido-5-chlorophenyl)-N-cyclohexyl-2-(3-phenylprop-2-ynyloxy)acetamide 

Relevant academic research and scientific papers

OPHA (oxidation-passerini-hydrolysis-alkylation) strategy: A four-step, one-pot improvement of the alkylative passerini reaction

Multicomponent reactions are often recognized for their efficiency and convergency, if compared with multistep organic synthesis. Nevertheless, we here demonstrate that a four-step-one-pot approach (named OPHA strategy for the initials of the four steps involved) is not only able to afford compounds that could not be obtained by an alkylative Passerini reaction but also capable of generating them with minimal loss of atoms and high operational simplicity, as in a typical multicomponent approach.