159298-66-5

Upstream product

• 110-91-8 morpholine 
• 949-01-9 1-(morpholin-4-yl)-2-phenylethanethione 
• 122-51-0 orthoformic acid triethyl ester 
• 22630-09-7 trimorpholylmethane 

Downstream Products

• 1042004-84-1 5-morpholin-4-yl-4-phenyl-thiophene-2-carboxylic acid (4-chloro-phenyl)-amide 
• 86673-62-3 (4-bromo-phenyl)-(5-morpholin-4-yl-4-phenyl-thiophen-2-yl)-methanone 
• 86673-60-1 (5-morpholin-4-yl-4-phenyl-thiophen-2-yl)-phenyl-methanone 
• 1042004-82-9 5-morpholin-4-yl-4-phenyl-thiophene-2-carboxylic acid m-tolylamide 
• 1042004-86-3 5-morpholin-4-yl-4-phenyl-thiophene-2-carboxylic acid naphthalen-1-yl-amide 
• 86673-59-8 1-(5-Morpholin-4-yl-4-phenyl-thiophen-2-yl)-ethanone 

Relevant academic research and scientific papers

Solvent-free synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents using KF-Al2O3 under microwave irradiation

The synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents catalyzed by KF-Al2O3 under microwave irradiation is reported. Copyright Taylor & Francis Group, LLC.

A simple route to N,N-dialkyl derivatives of 2-amino-5-thiophenecarboxylates

Starting from acetamides 4 and using three different routes - via thioacetamides 5, 3-amino-thioacrylamides 7, or 3-chloropropeniminium salts 6 - a series of new N,N-dialkyl derivatives of 2-amino-5-thiophenecarboxylates 10 has been prepared and analytically and spectroscopically characterized.

Efficient synthesis of 3-aminothioacrylamides by iminoformylation of thioacetamides

Heating substituted thioacetamides 1 with either trismorpholinomethane or with a mixture of triethyl orthoformate and a secondary amine gives high yields of synthetically versatile 3-aminothioacrylamides 4.