15930-56-0

Upstream product

• 7461-38-3 4-chloro-N,N-diethyl-benzamide 
• 693-04-9 butyl magnesium bromide 
• 95725-07-8 N,N-diethyl 4-N′,N′-dimethylaminobenzamide 
• 693-03-8 n-butyl magnesium bromide 
• 1469537-95-8 4-(diethylcarbamoyl)phenyltrimethylammonium triflate 

Relevant academic research and scientific papers

Gram-Scale, Cheap, and Eco-Friendly Iron-Catalyzed Cross-Coupling between Alkyl Grignard Reagents and Alkenyl or Aryl Halides

A new robust methodology for gram-scale iron-catalyzed cross-coupling between alkyl Grignard reagents and alkenyl or aryl halides is developed. This method does not require toxic additives such as NMP or expensive ligands. Its efficiency relies on the use of simple alkoxide magnesium salts as additives. On the basis of these results, a new procedure for one-pot synthesis of substituted benzamides from chloroesters is also proposed.

Iron-catalyzed cross-coupling of aryltrimethylammonium triflates and alkyl Grignard reagents

Fe(acac)3 effectively catalyzes reaction of aryltrimethylammonium triflates with β-hydrogen-containing primary or secondary alkyl Grignard reagents in a mixed solvent of THF and NMP at room temperature. A series of functional groups are tolerated under the reaction conditions.