159303-57-8Relevant academic research and scientific papers
Enzymatic synthesis of chiral, non-racemic phosphoryl compounds
Kie?basin?ski, Piotr,Miko?ajczyk, Marian
, p. 497 - 500 (2007/10/03)
A series of phosphinyl-, phosphonyl- and phosphorylacetates was hydrolyzed in the presence of Pig Liver Esterase (PLE) to give the corresponding P-chiral phosphoroacetic acids and unreacted esters in a high enantiomeric purity (up to 100% ee).
Stereoselective synthesis and resolution of P-chiral phosphine chalcogenides
Pietrusiewicz, K. Michal
, p. 573 - 576 (2007/10/03)
New synthetic methods and resolution procedures securing ready access to the resolved P-chiral phosphinoylethenes, phosphinoylacetates and secondary phosphine oxides of diversified structures have been developed. The methods are based on processes employing stereoselective nucleophilic displacement at phosphorus, asymmetric deprotonation, immolative vinyl and chirality transfer from sulfur to phosphorus, chemical and enzymatic kinetic resolution, resolution via covalent diastereoisomers, as well as direct resolution of racemates by classical resolving agents and by chromatography on chiral stationary phases.
Enzymatic Resolution of Racemic Phosphinoylacetates Having a Stereogenic Phosphorus Atom
Kielbasinski, Piotr,Zurawinski, Remigiusz,Pietrusiewicz, K. Michal,Zablocka, Maria,Mikolajczyk, Marian
, p. 7081 - 7084 (2007/10/02)
A series of racemic methyl alkylphenylphosphinoylacetates was hydrolyzed in the presence of pig liver esterase (PLE) to give the corresponding P-chiral phosphinoylacetic acids and unreacted esters in a high enantiomeric purity (72-100percent ee).
