159303-58-9Relevant academic research and scientific papers
Synthesis of P-chiral, non-racemic phosphinylacetates via enzymatic resolution of racemates
Kielbasinski,Zurawinski,Pietrusiewicz,Zablocka,Mikolajczyk
, p. 564 - 572 (2007/10/03)
A series of racemic methyl phosphinylacetates was hydrolyzed in the presence of porcine liver esterase (PLE) under the kinetic resolution conditions to give the corresponding P-chiral phosphinylacetic acids and recovered esters in high enantiomeric purity (72-100% ee). The Jones' active site model was applied to explain the enantioselectivity of this reaction.
Enzymatic synthesis of chiral, non-racemic phosphoryl compounds
Kie?basin?ski, Piotr,Miko?ajczyk, Marian
, p. 497 - 500 (2007/10/03)
A series of phosphinyl-, phosphonyl- and phosphorylacetates was hydrolyzed in the presence of Pig Liver Esterase (PLE) to give the corresponding P-chiral phosphoroacetic acids and unreacted esters in a high enantiomeric purity (up to 100% ee).
Enzymatic Resolution of Racemic Phosphinoylacetates Having a Stereogenic Phosphorus Atom
Kielbasinski, Piotr,Zurawinski, Remigiusz,Pietrusiewicz, K. Michal,Zablocka, Maria,Mikolajczyk, Marian
, p. 7081 - 7084 (2007/10/02)
A series of racemic methyl alkylphenylphosphinoylacetates was hydrolyzed in the presence of pig liver esterase (PLE) to give the corresponding P-chiral phosphinoylacetic acids and unreacted esters in a high enantiomeric purity (72-100percent ee).
