159309-75-8Relevant academic research and scientific papers
Synthesis of the (α,α-difluoroalkyl)phosphonate analogue of phosphoserine
Berkowitz, David B.,Shen, Quanrong,Maeng, Jun-Ho
, p. 6445 - 6448 (1994)
The synthesis of the (α,α-difluoroalkyl)phosphonate analogue of L- phosphoserine, 5, in a form appropriate for solid phase peptide synthesis, is reported. Two independent routes are described, starting from L-serine or (R)-isopropylideneglycerol. In each case, PCF2-C bond formation is achieved by triflate displacement with diethyl lithiodifluoromethylphosphonate.
