159326-71-3 Usage
Description
3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one is a heterocyclic compound characterized by its unique chemical structure, which features a pyrrolo and triazinone fused ring system. 3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one is known for its potential applications in the pharmaceutical and chemical industries due to its versatile chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one is used as a template for the synthesis of kinase inhibitors, which are important in the development of drugs targeting various diseases, including cancer and other conditions involving abnormal cell signaling.
Used in Chemical Synthesis:
3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one serves as a valuable intermediate in the synthesis of various complex organic molecules, particularly those with potential applications in the pharmaceutical, agrochemical, and materials science industries. Its unique structure allows for further functionalization and modification, making it a versatile building block in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 159326-71-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,3,2 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 159326-71:
(8*1)+(7*5)+(6*9)+(5*3)+(4*2)+(3*6)+(2*7)+(1*1)=153
153 % 10 = 3
So 159326-71-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H5N3O/c10-6-5-2-1-3-9(5)8-4-7-6/h1-4H,(H,7,8,10)
159326-71-3Relevant articles and documents
AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS
-
Page/Page column 190, (2019/08/12)
The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.
Synthesis of pyrrolo[2,1-f][1,2,4]triazine congeners of nucleic acid purines via the N-amination of 2-substituted pyrroles
Patil,Otter,Klein
, p. 781 - 786 (2007/10/02)
The synthesis of several new 4-mono- and 2,4-disubstituted pyrrolo[2,1-f][1,2,4]triazines is described. Key 1-aminopyrrole-2-carbonitrile intermediates 3 and 15 were obtained by N-amination of the corresponding pyrrole-2-carboxaldehyde followed by CHO → CN conversion with either hydroxylamine-O-sulfonic acid for 3 or O-mesitylenesulfonylhydroxylamine for 15. Cyclization of 3 or 15 with a variety of amidine reagents or, after conversion of 3 to its corresponding amide, base-catalyzed annulation completed the synthesis of the title products.