15934-77-7

Basic information

• Product Name: (2E)-1-(5-chloro-2-hydroxyphenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
• CAS NO: 15934-77-7
• Molecular Formula: C₁₇H₁₆ClNO₂
• Molecular Weight: 301.7674
• Mol File: 15934-77-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 497.2°C at 760 mmHg
• Flash Point: 254.5°C
• Density: 1.266g/cm³
• Vapor Pressure: 1.65E-10mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: (2E)-1-(5-chloro-2-hydroxyphenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(5-chloro-2-hydroxyphenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one(15934-77-7)
• EPA Substance Registry System: (2E)-1-(5-chloro-2-hydroxyphenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one(15934-77-7)

Safety Data

• Hazardous Substances Data: 15934-77-7(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2E)-1-(5-chloro-2-hydroxyphenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one" is an organic compound with a complex structure. It consists of a 1-(5-chloro-2-hydroxyphenyl) moiety linked to a 3-[4-(dimethylamino)phenyl]prop-2-en-1-one group. (2E)-1-(5-chloro-2-hydroxyphenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one has potential pharmaceutical applications due to its structural features, including a hydroxyphenyl and a dimethylamino phenyl group, which are of interest in drug development. Furthermore, the presence of the enone functional group suggests possible reactivity towards nucleophiles, making it a candidate for further chemical modification and study in medicinal chemistry and pharmacology.

Upstream product

• 876-27-7 4-chlorophenyl acetate 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 1363408-66-5 C₁₇H₁₆Br₂ClNO₂ 

Relevant articles and documents

Synthesis and biological activities of some new quinoxalines

The condensation of 5-chloro-2-hydroxyacetophenone 1 with different substituted aromatic aldehydes in ethanol in presence of strong alkali furnished 1-(2-hydroxy-5-chlorophenyl)-3-aryl propen-1-ones 2a-e. Bromination of compounds 2a-e in acetic acid gave 1-(2-hydroxy-5-chlorophenyl)-3-aryl 2,3-dibromopropan-1-ones 3a-e which upon treatment with o-phenylenediamine in methanol in presence of cone sulphuric acid underwent cyclization and resulted in the formation of quinoxaline derivatives 4ae. Structures of compounds were established on the basis of analytical and spectral studies. Further these compounds were evaluated for their antimicrobial activities and some selected compounds were evaluated for antitubercular activities.