159345-66-1

Basic information

• Product Name: Homopravastatin
• Synonyms: (bR,dR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-b,d,6-trihydroxy-2-methyl-8-[[(2S)-2-methyl-1-oxopentyl]oxy]-1-naphthaleneheptanoic Acid;Homopravastatin;(R,dR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-,d,6-trihydroxy-2-methyl-8-[[(2S)-2-methyl-1-oxopentyl]oxy]-1-naphthaleneheptanoic Acid;HoMopravastatin(Pentanol iMpurity);Pravastatin EP IMpurity C;(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[[(2S)-2-methylpentanoyl]oxy]-1,2,6,7,8,8ahexahydronaphthalen-1-yl]heptanoic acid
• CAS NO: 159345-66-1
• Molecular Formula: C24H38O7
• Molecular Weight: 438.557
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 159345-66-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Refractive Index: 1.551
• CAS DataBase Reference: Homopravastatin(CAS DataBase Reference)
• NIST Chemistry Reference: Homopravastatin(159345-66-1)
• EPA Substance Registry System: Homopravastatin(159345-66-1)

Safety Data

• Hazardous Substances Data: 159345-66-1(Hazardous Substances Data)

Usage

Uses

An impurity of Pravastatin

InChI:InChI=1/C24H38O7/c1-4-5-15(3)24(30)31-21-12-18(26)10-16-7-6-14(2)20(23(16)21)9-8-17(25)11-19(27)13-22(28)29/h6-7,10,14-15,17-21,23,25-27H,4-5,8-9,11-13H2,1-3H3,(H,28,29)/t14-,15-,17+,18+,19?,20-,21?,23-/m0/s1

Relevant articles and documents

Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses

Compounds of formula (I): STR1 [wherein R1 represents a group of formula (II) or (III): STR2 R2 is alkyl, alkenyl or alkynyl; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl; R5 is hydrogen or a carboxy-protecting group; Ra is hydrogen or a group of formula and --OR6 ; R6, R6a and R6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arylsulfonyl] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.