1593495-64-7

Basic information

• Product Name: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(phenyl)phosphinate
• Synonyms: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(phenyl)phosphinate
• CAS NO: 1593495-64-7
• Molecular Weight: 266.193
• Mol File: 1593495-64-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(phenyl)phosphinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(phenyl)phosphinate(1593495-64-7)
• EPA Substance Registry System: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(phenyl)phosphinate(1593495-64-7)

Safety Data

• Hazardous Substances Data: 1593495-64-7(Hazardous Substances Data)

Upstream product

• 2946-61-4 phenylphosphonous acid dimethyl ester 
• 51-20-7 5-bromouracil 

Relevant articles and documents

LaCl3.7H2O: An efficient catalyst for the synthesis of phosphinates (Michaelis-Arbuzov reaction) under neat conditions and their potential antimicrobial activity

An expeditious neat procedure was developed for the synthesis of a series of new methyl phenyl heterocyclic phosphinates (3a-l) through Michaelis-Arbuzov reaction by the reaction of various heterocyclic halides (Cl or Br) (1a-l) with dimethyl phenylphosphonite (2) under N2 atmosphere using a heterogeneous catalyst, LaCl3.7H2O. The advantages of the developed procedure are good yields (80-89%) of the products, less reaction time (2-3 h), avoiding toxic catalysts and harmful solvents and easy work-up procedure. Further, antimicrobial activity of the synthesized compounds was evaluated at different concentrations 50, 100 and 150 ?g/mL. Biological data revealed that compounds 3i, 3j and 3h, 3j exhibited potential antibacterial and antifungal activities, respectively, while the rest of the compounds showed moderate antimicrobial activity. Indian Academy of Sciences.