159350-97-7

Basic information

• Product Name: (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL
• Synonyms: (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL;(R)-2-Methoxymethoxy-1-propanol;MOM protected (R)-1,2-Propanediol;(R)-2-Ethoxypropane-1,2-diol;(2R)-2-(methoxymethoxy)propan-1-ol
• CAS NO: 159350-97-7
• Molecular Formula: C₅H₁₂O₃
• Molecular Weight: 120.15
• Product Categories: Chiral Compound
• Mol File: 159350-97-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 153.861 °C at 760 mmHg
• Flash Point: 75℃
• Appearance: /
• Density: 1.002 g/mL at 25 °C
• Vapor Pressure: 1.205mmHg at 25°C
• Refractive Index: n20/D1.415
• PKA: 14.35±0.10(Predicted)
• CAS DataBase Reference: (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL(159350-97-7)
• EPA Substance Registry System: (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL(159350-97-7)

Safety Data

• Hazard Codes: Xn
• Statements: 10-22-36/37/38
• Safety Statements: 26
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 159350-97-7(Hazardous Substances Data)

Usage

General Description

"(R)-(-)-2-(Methylmethoxy)-1,2-propanediol" is a chemical compound with the molecular formula C5H12O3. It is a chiral compound, meaning it has a non-superimposable mirror image, and specifically, it is the enantiomer of (S)-(+)-2-(methylmethoxy)-1,2-propanediol. (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL is used in the synthesis of pharmaceuticals and other organic compounds. It can also be used as a chiral building block in organic synthesis and as a resolving agent for racemic mixtures of enantiomers. Additionally, it has been studied for its potential use in the production of chiral catalysts and pharmaceutical intermediates due to its asymmetric catalytic properties. Overall, (R)-(-)-2-(methylmethoxy)-1,2-propanediol has various potential applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C5H12O3/c1-5(3-6)8-4-7-2/h5-6H,3-4H2,1-2H3/t5-/m1/s1

Upstream product

• 159350-96-6 isobutyl (R)-2-(methoxymethoxy)propionate 
• 16940-66-2 sodium tetrahydroborate 

Downstream Products

• 159350-99-9 (4R,5R)-5-methoxymethoxy-4-(p-methoxyphenyl)methoxy-1-hexene 
• 159351-00-5 (3R,4R)-4-methoxymethoxy-3-(p-methoxyphenyl)methoxypentanal 
• 159351-01-6 (4S,6R,7R)-6-(4-Methoxy-benzyloxy)-7-methoxymethoxy-oct-1-en-4-ol 
• 159351-02-7 (4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene 
• 159351-05-0 (3R,5R,6R)-3-(3,4-dimethoxyphenyl)methoxy-6-methoxymethoxy-5-<(p-methoxyphenyl)methoxy>heptanal 
• 159351-06-1 (4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octyne 
• 159351-07-2 methyl (5S,7R,8R)-5-(3,4-dimethoxyphenyl)methoxy-8-methoxymethoxy-7-<(p-methoxyphenyl)methoxy>non-2-ynoate 
• 1311285-20-7 N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2R)-2-(methoxymethoxy)propyl]oxy}-5-(trifluoromethyl)benzamide 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF ALKANEDIOL DERIVATIVES

The present invention provides a process for producing an alkanediol derivative represented by the general formula (II) from an ester compound represented by the general formula (I), safely without giving rise to racemization. The present invention lies in a process for producing an alcohol derivative represented by the following general formula (II): (wherein R2 and R3 are each independently a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; X is a hydrogen atom or a protecting group for hydroxyl group; and n is 0 or 1), which process comprises reducing an ester compound represented by the following general formula (I): (wherein R1 is an alkyl group having 1 to 4 carbon atoms; and R2, R3, X and n have the same definitions as given above) with sodium borohydride in a mixed solvent of at least one kind of solvent selected from the group consisting of aromatic hydrocarbons, aliphatic hydrocarbons and alicyclic hydrocarbons and a primary alcohol.