159351-81-2

Basic information

• Product Name: everolimus 42-bromoacetate
• Synonyms: everolimus 42-bromoacetate
• CAS NO: 159351-81-2
• Molecular Weight: 1079.17
• Mol File: 159351-81-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: everolimus 42-bromoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: everolimus 42-bromoacetate(159351-81-2)
• EPA Substance Registry System: everolimus 42-bromoacetate(159351-81-2)

Safety Data

• Hazardous Substances Data: 159351-81-2(Hazardous Substances Data)

Upstream product

• 5309-70-6 vinyl bromoacetate 
• 159351-69-6 everolimus 

Relevant articles and documents

Enzymic synthesis and biological evaluation of injectable glutathione-everolimus

An enzymic synthesis of glutathione-everolimus is reported. This process has been optimized and scaled up with high reproducibility and yields, which will facilitate the development of such conjugate. The stability of the conjugate supported that this prodrug can be prepared into lyophilized solid, which is to be reconstituted with 0.9% sodium chloride for injection before intravenous infusion. And the results of species-related drug release experiment displayed that the performance of the conjugate in human plasma, rat and monkey was similar. Moreover, the in vivo efficacy of glutathione-everolimus in the treatment of renal cell carcinoma was investigated in detail. The conjugate was proved to be an effective, safe and well-tolerated injectable prodrug in the treatment of renal cell carcinoma. The results indicated that three times injection with a high dosage in 1 week can achieve much better in vivo efficacy, and no obvious toxic response was observed.