15936-74-0 Usage
Uses
Used in Pharmaceutical Industry:
5-chloro-7-methyl-1H-indole-2-carboxylic acid is used as a key intermediate in the synthesis of various drugs and active pharmaceutical ingredients. Its chemical properties allow for the development of new drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
5-chloro-7-methyl-1H-indole-2-carboxylic acid is used as a building block in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals.
Used in Medicinal Chemistry:
5-chloro-7-methyl-1H-indole-2-carboxylic acid is used as a starting material for the development of new bioactive compounds in the field of medicinal chemistry. Its unique structure and reactivity enable the design and synthesis of novel compounds with potential therapeutic effects.
Used in Organic Chemistry:
5-chloro-7-methyl-1H-indole-2-carboxylic acid is used as a versatile intermediate in organic chemistry for the synthesis of various organic compounds. Its reactivity and functional groups make it a valuable building block for the preparation of complex organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 15936-74-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,9,3 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 15936-74:
(7*1)+(6*5)+(5*9)+(4*3)+(3*6)+(2*7)+(1*4)=130
130 % 10 = 0
So 15936-74-0 is a valid CAS Registry Number.
15936-74-0Relevant academic research and scientific papers
Detailed structure-activity relationship of indolecarboxamides as H 4 receptor ligands
Engelhardt, Harald,De Esch, Iwan J.P.,Kuhn, Daniel,Smits, Rogier A.,Zuiderveld, Obbe P.,Dobler, Julia,Mayer, Moriz,Lips, Sebastian,Arnhof, Heribert,Scharn, Dirk,Haaksma, Eric E.J.,Leurs, Rob
experimental part, p. 660 - 668 (2012/09/07)
A series of 76 derivatives of the indolecarboxamide 1 were synthesized, which allows a detailed SAR investigation of this well known scaffold. The data enable the definition of a predictive QSAR model which identifies several compounds with an activity comparable to 1. A selection of these new H 4R antagonists was synthesized and a comparison of predicted and measured values demonstrates the robustness of the model (47-55). In addition to the H4-receptor activity general CMC and DMPK properties were investigated. Some of the new analogs are not only excellently soluble, but display a significantly increased half-life in mouse liver microsomes as well. These properties qualify these compounds as a possible new standard for future in vivo studies (e.g 51, 52 and 55). Moreover, the current studies also provide valuable information on the potential receptor ligand interactions between the indolcarboxamides and the H4R protein.
