159388-68-8 Usage
Molecular structure
A 5-hydroxyindole ring with a 1-methylethyl group attached at the 6th position
Classification
Indole class of organic compounds
Synthesis use
Commonly used in the synthesis of various pharmaceuticals
Building block
Serves as a building block in organic chemistry
Pharmacological activities
Has potential as an enzyme inhibitor and has anti-inflammatory properties
Potential use
May be used in the treatment of certain diseases and disorders
Check Digit Verification of cas no
The CAS Registry Mumber 159388-68-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,3,8 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 159388-68:
(8*1)+(7*5)+(6*9)+(5*3)+(4*8)+(3*8)+(2*6)+(1*8)=188
188 % 10 = 8
So 159388-68-8 is a valid CAS Registry Number.
159388-68-8Relevant articles and documents
Synthesis and pharmacological evaluation of new indole derivatives structurally related to thymoxamine
Leonardi,Riva,De Toma,Boi,Pennini,Sironi
, p. 551 - 559 (2007/10/02)
The synthesis and pharmacological evaluation of a series of pyrrolidine analogues of thymoxamine allowed access to the basic SAR for the aromatic substitution pattern. The results confirm the relevance of the simultaneous presence of the hydroxy and methyl groups on the benzene ring and prompted us to prepare the corresponding indole congener. The principle of the phenol-indol bioisosterism was confirmed by the results obtained. The introduction of the N-(2-methoxyphenyl)piperazine moiety instead of pyrrolidine changed the receptor affinity profile and introduced a good uroselectivity.
