159427-70-0

Basic information

• Product Name: (2S)-N-<<1-(p-chlorobenzyl)-5-methyl-4-nitropyrazol-3-yl>carbonyl>pyrrolidine-2-carboxaldehyde diethyl thioacetal
• CAS NO: 159427-70-0
• Molecular Weight: 483.055
• Mol File: 159427-70-0.mol

Chemical Properties

• CAS DataBase Reference: (2S)-N-<<1-(p-chlorobenzyl)-5-methyl-4-nitropyrazol-3-yl>carbonyl>pyrrolidine-2-carboxaldehyde diethyl thioacetal(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-N-<<1-(p-chlorobenzyl)-5-methyl-4-nitropyrazol-3-yl>carbonyl>pyrrolidine-2-carboxaldehyde diethyl thioacetal(159427-70-0)
• EPA Substance Registry System: (2S)-N-<<1-(p-chlorobenzyl)-5-methyl-4-nitropyrazol-3-yl>carbonyl>pyrrolidine-2-carboxaldehyde diethyl thioacetal(159427-70-0)

Safety Data

• Hazardous Substances Data: 159427-70-0(Hazardous Substances Data)

Upstream product

• 159427-52-8 methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate 
• 105089-88-1 (2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole 
• 159427-57-3 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylic acid 

Downstream Products

• 1028263-83-3 [4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone 

Relevant articles and documents

Synthesis and antitumor activity of a new class of pyrazolo[4,3- e]pyrrolo[1,2-a][1,4]diazepinone analogues of pyrrolo[1,4][2,1- c]benzodiazepines

A new class of pyrrolo[1,4]benzodiazepine (PBD) analogues featuring a pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone ring system has been designed and synthesized. These compounds, 2a-o, are characterized by the substitution of the aromatic A ring, characteristic of the PBDs, with a disubstituted pyrazole ring bearing alkyl and benzyl substituents at N6 or N7 and alkyl or carbomethoxy substituents at C8. Biological evaluation revealed an appreciable in vitro cytotoxic activity for compounds 2a,b,f-i.