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159428-42-9

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159428-42-9 Usage

Description

Bis-propargyl-PEG5 is a crosslinker containing propargyl groups at both ends. The propargyl groups reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form stable triazole linkages.

Check Digit Verification of cas no

The CAS Registry Mumber 159428-42-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,4,2 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 159428-42:
(8*1)+(7*5)+(6*9)+(5*4)+(4*2)+(3*8)+(2*4)+(1*2)=159
159 % 10 = 9
So 159428-42-9 is a valid CAS Registry Number.

159428-42-9Relevant articles and documents

PH responsive polymersome Pickering emulsion for simple and efficient Janus polymersome fabrication

Wang, Zhipeng,Rutjes, Floris P. J. T.,Van Hest, Jan C. M.

, p. 14550 - 14553 (2014)

Crosslinked poly(acrylic acid)-b-polystyrene polymersomes were successfully employed to form a water-in-oil Pickering emulsion and enabled an easy and reversible disassembly due to the pH sensitivity. The side of the polymersomes exposed to the water phase was selectively modified with metal nanoparticles, allowing facile formation of anisotropically modified Janus polymersomes. This journal is

Kinetics of bulk azide/alkyne "click" polymerization

Sheng, Xia,Mauldin, Timothy C.,Kessler, Michael R.

, p. 4093 - 4102 (2010)

A bulk step-growth polymerization of multifunctional azides and alkynes through the copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is described. The polymerization kinetics of two systems containing different diynes, bisphenol E diyne (BE-diyne)Zbisphenol A bisazide (BAbisazide) and tetraethylene glycol diyne (TeEG-diyne)/BA-bisazide, are evaluated by differential scanning calorimetry (DSC), shear rheology, and thermogravimetric analysis. The effects of catalyst concentration on reaction kinetics are investigated In detail, as are the thermal properties (glass transition and decomposition temperatures) of the formed polymers.

Tumor-Targeted Boranes. 4. Synthesis of Nitroimidazole-Carboranes with Polyether-Isoxazole Links

Scobie, Martin,Threadgill, Michael D.

, p. 7008 - 7013 (1994)

Carboranes targeted to specific tumor tissues are important for boron neutron capture therapy (BNCT) of cancer.Previous attempts to use isoxazolylphenyl-linked nitroimidazole-carboranes for targeting to hypoxic tumors were hampered by the low polarity and very low aqueous solubility of the compounds.Syntheses of polyether-linked nitroimidazole-isoxazole-carborane 17, 25, and 26 via 1,3-dipolar cycloaddition of appropriate nitroimidazole-alkynes with nitrile oxides derived from aliphatic aldehyde oximes linked by a varying number of water-solubilizing ether units to carborane have been developed.The stabilities of the nitrile oxides were much less than that of the corresponding 4-(carboranylmethoxy)phenyl nitrile oxide and depended on their structure.The yields of isoxazoles varied accordingly and cycloaddition failed when eight ether units were included in the chain.Compounds 17, 25, and 26, with four, five, and six ether units, respectively, had increasingly convenient physical properties to permit biological evaluation.

DIMERIC IMMUNO-MODULATORY COMPOUNDS AGAINST CEREBLON-BASED MECHANISMS

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Page/Page column 71; 77; 78, (2020/02/06)

Disclosed are small molecules against cereblon to enhance effector T cell function. Methods of making these molecules and methods of using them to treat various disease states are also disclosed.

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