159429-52-4Relevant articles and documents
Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system
Gavryushin, Andrei,Kofink, Christiane,Manolikakes, Georg,Knochel, Paul
, p. 4871 - 4874 (2005)
(Chemical Equation Presented) The combination of diethyl phosphite and DMAP as ligands for nickel in an 8:1 THF-N-ethylpyrrolidinone (NEP) mixture allows a very efficient cross-coupling reaction to be performed between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides. The reaction proceeds at 25°C within 1-48 h and requires only 0.05 mol % of the nickel catalyst.
An efficient Negishi cross-coupling reaction catalyzed by nickel(II) and diethyl phosphite
Gavryushin, Andrei,Kofink, Christiane,Manolikakes, Georg,Knochel, Paul
, p. 7521 - 7533 (2007/10/03)
A combination of diethyl phosphite-DMAP and Ni(II) salts forms a very effective catalytic system for the cross-coupling reactions of arylzinc halides with aryl, heteroaryl, and alkenyl bromides, chlorides, triflates, and nonaflates. The choice of solvent is quite important and the mixture of THF-N-ethylpyrrolidinone (NEP) (8:1) was found to be optimal. The reaction usually requires only 0.05 mol % of NiCl2 or Ni(acac)2 as catalyst and proceeds at room temperature within 1-48 h.
