159429-52-4Relevant academic research and scientific papers
Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system
Gavryushin, Andrei,Kofink, Christiane,Manolikakes, Georg,Knochel, Paul
, p. 4871 - 4874 (2005)
(Chemical Equation Presented) The combination of diethyl phosphite and DMAP as ligands for nickel in an 8:1 THF-N-ethylpyrrolidinone (NEP) mixture allows a very efficient cross-coupling reaction to be performed between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides. The reaction proceeds at 25°C within 1-48 h and requires only 0.05 mol % of the nickel catalyst.
Nickel or Iron Catalysed Carbon-Carbon Coupling Reaction of Arylenes, Alkenes and Alkines
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Page/Page column 5-6, (2010/08/07)
Organozinc compounds of the type R1—Ar1—ZnY (1) can be reacted with different functionalized aryl halides R2—Ar2—X (2) in the presence of catalytic amounts of Ni or Fe in a polar solvent or solvent mixture to form polyfunctional biaryles of the type R1—Ar1—Ar2—R2 (3). Organozinc compounds of the type (1) can be represented by the transmetallation reaction of functionalized aryl magnesium halides or lithium aryl compounds with e.g. ZnBr2.
An efficient Negishi cross-coupling reaction catalyzed by nickel(II) and diethyl phosphite
Gavryushin, Andrei,Kofink, Christiane,Manolikakes, Georg,Knochel, Paul
, p. 7521 - 7533 (2007/10/03)
A combination of diethyl phosphite-DMAP and Ni(II) salts forms a very effective catalytic system for the cross-coupling reactions of arylzinc halides with aryl, heteroaryl, and alkenyl bromides, chlorides, triflates, and nonaflates. The choice of solvent is quite important and the mixture of THF-N-ethylpyrrolidinone (NEP) (8:1) was found to be optimal. The reaction usually requires only 0.05 mol % of NiCl2 or Ni(acac)2 as catalyst and proceeds at room temperature within 1-48 h.
Inhibition of Myeloperoxidase Release from Rat Polymprphonuclear Leukocytes by a Series of Azachalcone Derivatives
Edwards, Michael L.,Stemerick, David M.,Sabol, Jeffrey S.,Diekema, Keith A.,Dinerstein, Robert J.
, p. 4357 - 4362 (2007/10/02)
A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes by fMLP.The compounds were found to interfere with cellular uptake of extracellular calcium.Structure-activity relationships are
