159435-10-6

Basic information

• Product Name: 6-Aminotetramethylrhodamine
• Synonyms: 6-AMino-3',6'-bis(diMethylaMino)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one;6-AMinotetraMethylrhodaMine [XanthyliuM, 9-(5-aMino-2-carboxyphenyl)-3,6-bis(diMethylaMino)-, inner salt]
• CAS NO: 159435-10-6
• Molecular Formula: C₂₄H₂₃N₃O₃
• Molecular Weight: 401.464
• Product Categories: Miscellaneous Reagents;Heteroccles;Amines;Aromatics;Amines, Aromatics, Heteroccles, Miscellaneous Reagents
• Mol File: 159435-10-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: >300°C (dec.)
• Boiling Point: 675 °C at 760 mmHg
• Flash Point: 362 °C
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 4.46E-18mmHg at 25°C
• Refractive Index: 1.712
• Storage Temp.: -20°C Freezer
• PKA: 4.10±0.20(Predicted)
• CAS DataBase Reference: 6-Aminotetramethylrhodamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Aminotetramethylrhodamine(159435-10-6)
• EPA Substance Registry System: 6-Aminotetramethylrhodamine(159435-10-6)

Safety Data

• Hazardous Substances Data: 159435-10-6(Hazardous Substances Data)

Usage

Chemical Properties

Dark Purple Solid

Uses

Different sources of media describe the Uses of 159435-10-6 differently. You can refer to the following data:
1. Biulding Block
2. Synthetic Intermediat

InChI:InChI=1/C24H23N3O3/c1-26(2)15-6-9-18-21(12-15)29-22-13-16(27(3)4)7-10-19(22)24(18)20-11-14(25)5-8-17(20)23(28)30-24/h5-13H,25H2,1-4H3

Upstream product

• 5466-84-2 4-nitrophthalic anhydride 
• 159435-02-6 methyl 2-(4'-dimethylamino-2'-hydroxybenzoyl)-4-nitrobenzoate 
• 166442-37-1 4-acetamido-2-(4'-dimethylamino-2'-hydroxybenzoyl)benzoic acid 
• 1026132-88-6 4-Amino-2-(4-dimethylamino-2-hydroxy-benzoyl)-benzoic acid methyl ester 
• 159435-06-0 6-acetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 
• 610-27-5 4-nitrophthalic acid 

Downstream Products

• 159435-00-4 6-iodoacetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 
• 159435-08-2 6-chloroacetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 

Relevant articles and documents

Convenient synthesis of regioisomerically pure 5- and 6-functionalized xanthene dyes via SNAr reaction and comparison of their reactivity towards click reaction

In this study, we present an efficient and general strategy for the individual preparation of both isomers of 5(6)-functionalized xanthene-based fluorophores. Spectroscopic analysis of the acid-base equilibrium of 5(6)-nitro xanthene dyes has shown that they exist predominantly in the colorless spirolactone form in certain aprotic dipolar solvents. In such solvents, regioisomerically selective ipso-substitution of the nitro group by sodium azide occurs at the 6- position but not at the 5- position due to the electron-withdrawing spirolactone moiety at the para-position, relative to the nitro group. This reaction allows the separation of the isomer with the 6-azide group and the intact 5-nitro isomer. The 5-nitro group of the latter was then reduced to an amino group and subsequently converted to an azide group. This strategy enables the preparation of both the 5- and 6-functionalized isomers individually from a mixture of precursors, which is otherwise unachievable. The azide isomers were then compared in reactivity by strain-promoted azide-alkyne cycloaddition (SPAAC) with bicycle[6.1.0]non-4-yene (BCN).