15944-33-9

Usage

Uses

Used in Pharmaceutical Synthesis:
7-chloro-1,8-naphthyridin-2-amine is utilized as a building block in the synthesis of pharmaceuticals due to its functional groups and reactivity. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Synthesis:
In the agrochemical industry, 7-chloro-1,8-naphthyridin-2-amine serves as a key component in the creation of various agrochemicals. Its reactivity and functional groups enable the production of compounds that can be used in crop protection and other agricultural applications.
Used in Medicinal Chemistry Research:
7-chloro-1,8-naphthyridin-2-amine is being studied for its potential use in medicinal chemistry due to its biological activity. Researchers are exploring its properties to understand its potential role in the development of new therapeutic agents and treatments for various diseases and conditions.

InChI:InChI=1/C8H6ClN3/c9-6-3-1-5-2-4-7(10)12-8(5)11-6/h1-4H,(H2,10,11,12)

Upstream product

• 1931-44-8 2-amino-8H-7-oxo-[1,8]-naphthyridine 
• 1931-44-8 2-amino-7-hydroxy-1,8-naphthyridine 
• 141-86-6 2.6-diaminopyridine 

Downstream Products

• 103255-66-9 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one 
• 898258-05-4 2-amino-7-benzylamino-1,8-naphthyridine 
• 898258-02-1 2-amino-7-azido-1,8-naphthyridine 
• 145325-89-9 2,7-bisamino-1,8-naphthyridine 
• 107739-06-0 2-amino-7-phenoxy-1,8-naphthyridine 

Relevant academic research and scientific papers

Unsymmetrical Naphthyridine-Based Dicopper(I) Complexes: Synthesis, Stability, and Carbon-Hydrogen Bond Activations

Two unsymmetrical dinucleating naphthyridine-based ligands with di(pyridyl) and phosphino side arms were employed in the synthesis of dicopper(I) chloride cores that activate NaBPh4to afford bridging phenyl organocopper complexes. In these compounds, the bridging ligand binds symmetrically, as observed in previously described symmetrical dicopper(I) complexes supported by naphthyridine-based ligands with two di(pyridyl) side arms. Unlike the symmetrical systems, however, these complexes undergo quasireversible electrochemical reductions, and chemical reduction yields a diamagnetic product resulting from the coupling of naphthyridine-based radicals of two complexes. The μ-Ph complexes activate the C-H bonds of terminal alkynes and the electron-poor arene C6F5H. By DFT calculations, the mechanism of terminal alkyne activation involves H-atom transfer at the cationic dicopper center and is sensitive to subtle changes in copper-ligand interactions as well as the position of the anion.

Naphthyridine-based iridium complexes: Structures and catalytic activity on alkylation of aryl ketones

Iridium(III) complexes containing a designed ligand, 2-amino-7-(2-pyridinyl)-1,8-naphthyridine derivative, were prepared and all complexes were characterized using spectroscopic and crystallographic methods. These new Ir(III) complexes are able to act as catalysts for the C-alkylation of aryl alkyl ketones with the use of alcohols as the alkylating agent. Typically, acetophenone undergoes alkylation with methanol and ethanol to yield isobutyrophenone and butyrophenone, respectively.

Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives

We report that a polyhedral oligomeric silsesquioxane (POSS) core in a dendrimer can enhance the affinity of the molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides. The complexation of the naphthyridine ligands with a series of guanosine nucleotides was investigated, and it is shown that the POSS core should play a significant role in the stabilization of the complexes via hydrogen bonds. Finally, we demonstrate that the 1,8-naphthyridine ligand can selectively recognize guanosine triphosphate by assisting with the POSS-core dendrimer.

Simple and efficient synthesis of 2,7-difunctionalized-1,8-naphthyridines

The syntheses in good yields of some new difunctionalized 1,8-naphthyridines 4, 6, 8 and 9 and a novel triethylene glycol ether-linked dinaphthyridine, 10a, along with the mononaphthyridine-linked ether alcohol 10b are described. An improved and milder method for the synthesis of 2,7-diamino-1,8-naphthyridine (14) is also reported.