159448-38-1

Upstream product

• 554-14-3 2-Methylthiophene 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 610-94-6 2-bromobenzoic acid methyl ester 

Downstream Products

• 159448-40-5 methyl 2-<2-(bromomethyl)thien-5-yl>benzoate 
• 159448-63-2 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>thien-5-yl>methyl>-1H-imidazole 
• 164460-41-7 2-[5-(2-Butyl-5-chloro-4-hydroxymethyl-imidazol-1-ylmethyl)-thiophen-2-yl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

Direct C-H arylation of thiophenes at low catalyst loading of a phosphine-free bis(alkoxo)palladium complex

An efficient phosphine-free direct C-H arylation of thiophenes at the α-position has been developed at low catalyst loading of bis(alkoxo)palladium complex (Cat.I, 0.1-0.2 mol %). The developed synthetic method can be applied to the synthesis of α-aryl/heteroaryl thiophenes from aryl or heteroaryl bromides in good to excellent yields and is compatible with the substrates bearing electron-donating or electron-withdrawing groups. The reactivities of the 2- and 5-positions of thiophenes are equivalent and not dependent on steric hindrance under optimal conditions. This condition can also be applied to other heterocyclic moieties such as benzothiophene, benzofuran, and pyrrole with high conversion yields.

Imidazole ethers having a II antagonist activity

Compounds of general formula (I) STR1 wherein E is O or S; R is C 1 -C 5 straight, branched or cyclic alkyl or C 2 -C 5 alkenyl; X can be H, F, Cl, Br, I, CF 3 ; n is an integer 1 to 4; m is an integer 0 to 4; A and B are 5- or 6- membered aromatic carboc

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in Vitro Activity, and Molecular Modeling Studies of N-imidazoles

With the aim of explaining the influence of the structural changes on the biphenylic moiety on the activity, a series of N-imidazoles (I), constructed on the model of DuPont compounds by replacing either the central or terminal pheny