15945-07-0

Basic information

• Product Name: 2,4,5-TRICHLOROBENZENESULFONYL CHLORIDE
• Synonyms: AKOS 213-16;2,4,5-TRICHLOROBENZENE-1-SULFONYL CHLORIDE;2,4,5-TRICHLOROBENZENESULFONYL CHLORIDE;2,4,5-TRICHLOROBENZENESULPHONYL CHLORIDE;2,4,5-trichloro-benzenesulfonylchlorid;2,4,5-Trichlorobenzenesulfonyl chloride, GC 97%;2,4,5-THRICHLOROBENZENESULFONYL CHLORIDE;2,4,5-TRICHLOROBENZENESULFONYL CHLORIDE 98+%
• CAS NO: 15945-07-0
• Molecular Formula: C₆H₂Cl₄O₂S
• Molecular Weight: 279.96
• EINECS: 240-079-0
• Product Categories: Benzenesulfonyl chloride;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 15945-07-0.mol

Chemical Properties

• Melting Point: 68-70°C
• Boiling Point: 344.966 °C at 760 mmHg
• Flash Point: 162.43 °C
• Appearance: White or cream solid
• Density: 1.729 g/cm³
• Vapor Pressure: 0.000127mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Store at RT.
• Solubility: soluble in Toluene
• Sensitive: Moisture Sensitive
• BRN: 1112595
• CAS DataBase Reference: 2,4,5-TRICHLOROBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRICHLOROBENZENESULFONYL CHLORIDE(15945-07-0)
• EPA Substance Registry System: 2,4,5-TRICHLOROBENZENESULFONYL CHLORIDE(15945-07-0)

Safety Data

• Hazard Codes: C
• Statements: 34-14
• Safety Statements: 26-27-36/37/39-8-45
• RIDADR: 3261
• WGK Germany: 3
• TSCA: T
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 15945-07-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4,5-Trichlorobenzenesulfonyl chloride is used as a building block for organic synthesis due to its reactive nature and unique structural features. The presence of the sulfonyl chloride group allows for further functionalization and the formation of various chemical compounds with different properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4,5-trichlorobenzenesulfonyl chloride is used as an intermediate for the synthesis of various drugs and drug candidates. Its reactivity and structural diversity make it a valuable component in the development of new medications with potential therapeutic benefits.
Used in Chemical Research:
2,4,5-Trichlorobenzenesulfonyl chloride is also employed in chemical research as a versatile reagent for studying reaction mechanisms and exploring new synthetic pathways. Its unique properties and reactivity enable researchers to gain insights into various chemical processes and develop innovative strategies for the synthesis of complex molecules.
Used in Material Science:
In the field of material science, 2,4,5-trichlorobenzenesulfonyl chloride can be used as a precursor for the development of novel materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of new compounds with enhanced characteristics, such as improved stability, reactivity, or selectivity.

InChI:InChI=1/C6H2Cl4O2S/c7-3-1-5(9)6(2-4(3)8)13(10,11)12/h1-2H

Upstream product

• 120-82-1 1,2,4-Trichlorobenzene 
• 3808-87-5 2,4,5-trichlorophenyl disulfide 

Downstream Products

• 3808-87-5 2,4,5-trichlorophenyl disulfide 
• 29092-27-1 2,4,5-trichloro-benzenesulfonic acid amide 
• 116-29-0 tetradifon 
• 10439-21-1 2,4,5-trichloro-benzenesulfinic acid 
• 3653-54-1 phenyl-(2,4,5-trichloro-phenyl)-sulfone 
• 4864-65-7 2,4,5-trichloro-benzenesulfonic acid-(4-chloro-anilide) 
• 7709-15-1 2,4,5-trichloro-benzenesulfonic acid anilide 
• 105582-99-8 2,4,5-trichloro-benzenesulfonic acid phenyl ester 
• 13607-32-4 4-(2,4,5-trichloro-benzenesulfonyl)-morpholine 
• 72672-87-8 3-ethyl-2-methyl-4-(2,4,5-trichloro-benzenesulfonyl)-thiomorpholine 
• 93881-97-1 1.6-Bis-<2.4.5-trichlor-benzolsulfonyl-amino>-hexan 
• 4864-66-8 N-(Pentachlor-phenyl)-2,4,5-trichlor-benzolsulfonsaeureamid 
• 6655-72-7 2,4,5-trichloro-benzenesulfonic acid hydrazide 
• 3773-14-6 2,4,5-trichlorothiophenol 

Relevant articles and documents

A simple and highly effective oxidative chlorination protocol for the preparation of arenesulfonyl chlorides

2,4-Dichloro-5,5-dimethylhydantoin (DCDMH) was found to be a mild and efficient reagent for the direct oxidative conversion of sulfur compounds to the corresponding arenesulfonyl chlorides in good to excellent yields through oxidative chlorination. The method is suitable for many types of sulfur substrates (thiols, disulfides, and benzylic sulfides). The overall process is simple, practical, and it provides convenient access to a variety of aryl or heteroarylsulfonyl chlorides. The mild reaction conditions and the broad substrate scope render this method attractive and complementary to existing syntheses of aryl or heteroarylsulfonyl chlorides.

Substituted Disulfonamide Compounds

Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.