15945-75-2

Basic information

• Product Name: 2-CHLORO-5-METHYLSULFANYL-PHENYLAMINE
• Synonyms: 2-CHLORO-5-METHYLSULFANYL-PHENYLAMINE;2-chloro-5-(Methylthio)aniline;2-CHLORO-5-(METHYLSULFANYL)ANILINE
• CAS NO: 15945-75-2
• Molecular Formula: C₇H₈ClNS
• Molecular Weight: 173.66312
• Mol File: 15945-75-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-5-METHYLSULFANYL-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-METHYLSULFANYL-PHENYLAMINE(15945-75-2)
• EPA Substance Registry System: 2-CHLORO-5-METHYLSULFANYL-PHENYLAMINE(15945-75-2)

Safety Data

• Hazardous Substances Data: 15945-75-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-methylsulfanyl-phenylamine is a chemical compound with the molecular formula C7H8ClNS. It is a white solid that is soluble in organic solvents. 2-CHLORO-5-METHYLSULFANYL-PHENYLAMINE is known to have applications in the field of organic synthesis and pharmaceutical research. Its structure contains a chloro group and a methylsulfanyl group attached to a phenylamine moiety, and it is used as a building block in the synthesis of various organic compounds and pharmaceutical intermediates. Its properties and reactivity make it a valuable chemical for use in the production of a wide range of products.

Upstream product

• 1199-36-6 1-chloro-4-(methylthio)-2-nitrobenzene 
• 108-24-7 acetic anhydride 
• 51546-12-4 2-chloro-5-(methylthio)benzoic acid 

Downstream Products

• 342042-24-4 2-chloro-5-methanesulfinyl-phenyl-cyanamide 

Relevant articles and documents

N′-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N′-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl- d -aspartate (NMDA) Receptor: Synthesis and Structure-Affinity Relationships

N-Methyl-d-aspartate (NMDA) receptor dysfunction has been linked to several neuropsychiatric disorders, including Alzheimer's disease, epilepsy, drug addiction, and schizophrenia. A radioligand that could be used with PET to image and quantify human brain NMDA receptors in the activated "open channel" state would be useful for research on such disorders and for the development of novel therapies. To date, no radioligands have shown well-validated efficacy for imaging NMDA receptors in human subjects. In order to discover improved radioligands for PET imaging, we explored structure-affinity relationships in N′-3-(trifluoromethyl)phenyl derivatives of N-aryl-N′-methylguanidines, seeking high affinity and moderate lipophilicity, plus necessary amenability for labeling with a positron-emitter, either carbon-11 or fluorine-18. Among a diverse set of 80 prepared N′-3-(trifluoromethyl)phenyl derivatives, four of these compounds (13, 19, 20, and 36) displayed desirable low nanomolar affinity for inhibition of [3H](+)-MK801 at the PCP binding site and are of interest for candidate PET radioligand development.

A convenient synthesis of 2-methyl-5-(methylthio)benzothiazole

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