159461-16-2Relevant academic research and scientific papers
3-Urea-1-(phenylmethyl)-pyridones as novel, potent, and selective EP 3 receptor antagonists
Li, Yue H.,Tseng, Pei-San,Evans, Karen A.,Jaworski, Jon-Paul,Morrow, Dwight M.,Fries, Harvey E.,Wu, Charlene W.,Edwards, Richard M.,Jin, Jian
scheme or table, p. 6744 - 6747 (2010/12/20)
A series of 3-urea-1-(phenylmethyl)-pyridones was discovered as novel EP3 antagonists via high-throughput screening and subsequent optimization. The synthesis, structure-activity relationships, and optimization of the initial hit that resulted in potent and selective EP3 receptor antagonists such as 11g are described.
